| SP | Johnson, W.Johnson, Walter † $ >> | 26 | 1913 | R | 95 | 26 | 26 | 12 | 8 | 4.18 | .293 | 1.22 | 9.2 | 1.9 | 5.4 | 178.2 | 181 | 88 | 83 | 16 | 37 | 107 | 4 | 0 | 0 | 0 | 13 | 4 | 4 | 3.66 |
| SP | Leonard, D.Leonard, Dutch $ >> | 22 | 1914 | L | 91 | 26 | 26 | 10 | 8 | 4.12 | .293 | 1.23 | 7.6 | 3.5 | 4.7 | 168.1 | 141 | 79 | 77 | 17 | 66 | 87 | 1 | 0 | 0 | 0 | 16 | 2 | 1 | 4.49 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 25 | 25 | 7 | 8 | 5.57 | .318 | 1.40 | 10.1 | 2.5 | 8.2 | 160.0 | 179 | 104 | 99 | 29 | 45 | 145 | 1 | 0 | 0 | 0 | 9 | 0 | 5 | 4.39 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 78 | 26 | 25 | 6 | 8 | 5.77 | .337 | 1.50 | 9.6 | 3.9 | 5.8 | 112.1 | 119 | 77 | 72 | 18 | 49 | 72 | 0 | 1 | 0 | 0 | 7 | 3 | 2 | 5.20 |
| CL | Jansen, K.Jansen, Kenley † >> | 28 | 2016 | R | 97 | 65 | 0 | 4 | 6 | 2.47 | .278 | 1.15 | 8.5 | 2.0 | 10.2 | 69.1 | 65 | 22 | 19 | 4 | 15 | 78 | 0 | 38 | 4 | 0 | 0 | 0 | 0 | 2.14 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 57 | 0 | 2 | 1 | 3.45 | .310 | 1.33 | 7.8 | 4.2 | 9.0 | 60.0 | 52 | 24 | 23 | 8 | 28 | 60 | 0 | 6 | 4 | 0 | 0 | 1 | 0 | 4.18 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 61 | 0 | 7 | 3 | 5.14 | .334 | 1.49 | 9.7 | 3.8 | 8.2 | 68.1 | 73 | 43 | 39 | 13 | 29 | 62 | 0 | 1 | 2 | 0 | 0 | 1 | 2 | 4.99 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 47 | 0 | 4 | 3 | 4.66 | .328 | 1.43 | 9.0 | 3.9 | 6.8 | 56.0 | 56 | 32 | 29 | 9 | 24 | 42 | 0 | 1 | 2 | 0 | 0 | 2 | 0 | 4.98 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 71 | 39 | 0 | 4 | 2 | 3.52 | .310 | 1.30 | 8.0 | 3.7 | 7.6 | 46.0 | 41 | 21 | 18 | 4 | 19 | 39 | 0 | 2 | 1 | 0 | 0 | 2 | 4 | 3.80 |