| SP | deGrom, J.deGrom, Jacob $$ >> | 33 | 2021 | R | 100 | 20 | 20 | 9 | 7 | 3.21 | .268 | 1.08 | 7.1 | 2.6 | 8.9 | 137.1 | 108 | 55 | 49 | 15 | 40 | 136 | 0 | 0 | 0 | 0 | 15 | 3 | 0 | 3.38 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 19 | 19 | 6 | 7 | 5.57 | .325 | 1.43 | 9.3 | 3.6 | 7.2 | 105.0 | 108 | 68 | 65 | 18 | 42 | 84 | 0 | 0 | 0 | 0 | 9 | 2 | 4 | 4.89 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 85 | 19 | 19 | 3 | 11 | 6.51 | .344 | 1.53 | 11.2 | 2.7 | 3.6 | 92.2 | 114 | 75 | 67 | 13 | 28 | 37 | 0 | 0 | 0 | 0 | 3 | 4 | 3 | 5.08 |
| CL | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 97 | 42 | 0 | 2 | 4 | 4.37 | .303 | 1.28 | 8.0 | 3.6 | 8.8 | 45.1 | 40 | 22 | 22 | 8 | 18 | 44 | 0 | 20 | 5 | 0 | 0 | 1 | 2 | 4.62 |
| SU | Gossage, R.Gossage, Rich >> | 30 | 1981 | R | 90 | 46 | 0 | 1 | 2 | 4.67 | .357 | 1.62 | 7.8 | 7.0 | 9.8 | 44.1 | 38 | 28 | 23 | 3 | 34 | 48 | 0 | 4 | 3 | 0 | 0 | 2 | 1 | 4.16 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 82 | 46 | 0 | 4 | 2 | 4.59 | .320 | 1.37 | 7.8 | 4.6 | 8.6 | 51.0 | 44 | 27 | 26 | 11 | 26 | 49 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 5.53 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 44 | 0 | 1 | 4 | 6.85 | .360 | 1.69 | 11.3 | 4.0 | 9.0 | 47.1 | 59 | 39 | 36 | 7 | 21 | 47 | 0 | 2 | 1 | 0 | 0 | 0 | 3 | 4.28 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 71 | 39 | 0 | 4 | 0 | 4.81 | .338 | 1.53 | 8.2 | 5.7 | 8.8 | 43.0 | 39 | 23 | 23 | 3 | 27 | 42 | 0 | 1 | 1 | 0 | 0 | 0 | 3 | 3.84 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 22 | 0 | 3 | 0 | 4.83 | .344 | 1.54 | 10.7 | 3.3 | 5.0 | 85.2 | 101 | 61 | 46 | 10 | 31 | 47 | 0 | 2 | 0 | 0 | 0 | 3 | 4 | 4.62 |