| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 20 | 20 | 7 | 7 | 4.14 | .292 | 1.20 | 7.7 | 3.1 | 8.2 | 132.2 | 113 | 61 | 61 | 17 | 46 | 120 | 1 | 0 | 0 | 0 | 13 | 5 | 2 | 4.02 |
| SP | Alexander, P.Alexander, Pete # >> | 28 | 1915 | R | 88 | 19 | 19 | 8 | 9 | 4.88 | .312 | 1.32 | 9.2 | 2.7 | 5.6 | 131.0 | 134 | 78 | 71 | 24 | 39 | 81 | 6 | 0 | 0 | 1 | 9 | 5 | 1 | 5.15 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 75 | 19 | 19 | 9 | 6 | 4.32 | .310 | 1.31 | 8.7 | 3.1 | 4.1 | 133.1 | 129 | 64 | 64 | 14 | 46 | 60 | 3 | 0 | 0 | 1 | 9 | 5 | 0 | 4.62 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 18 | 18 | 5 | 9 | 4.64 | .315 | 1.37 | 9.1 | 3.3 | 5.0 | 130.0 | 131 | 71 | 67 | 15 | 47 | 72 | 1 | 0 | 0 | 0 | 8 | 1 | 0 | 4.50 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 18 | 18 | 8 | 8 | 5.15 | .345 | 1.55 | 10.8 | 3.2 | 4.6 | 117.0 | 140 | 71 | 67 | 14 | 41 | 60 | 3 | 0 | 0 | 1 | 9 | 4 | 2 | 4.68 |
| CL | Wagner, B.Wagner, Billy † >> | 28 | 1999 | L | 95 | 46 | 0 | 3 | 2 | 4.11 | .317 | 1.37 | 8.4 | 3.9 | 7.6 | 46.0 | 43 | 24 | 21 | 5 | 20 | 39 | 0 | 26 | 1 | 0 | 0 | 1 | 0 | 4.09 |
| SU | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 91 | 41 | 0 | 3 | 1 | 4.33 | .284 | 1.19 | 7.5 | 3.3 | 7.5 | 43.2 | 36 | 22 | 21 | 4 | 16 | 36 | 0 | 1 | 5 | 0 | 0 | 0 | 0 | 3.65 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 79 | 47 | 0 | 3 | 3 | 3.44 | .352 | 1.55 | 8.6 | 5.5 | 8.1 | 49.2 | 47 | 19 | 19 | 2 | 30 | 44 | 0 | 2 | 4 | 0 | 0 | 4 | 1 | 3.82 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 74 | 28 | 0 | 2 | 0 | 4.50 | .359 | 1.68 | 8.7 | 6.4 | 12.5 | 28.0 | 27 | 17 | 14 | 4 | 20 | 39 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 4.21 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 69 | 26 | 0 | 1 | 0 | 3.07 | .290 | 1.23 | 8.4 | 2.8 | 9.0 | 29.1 | 27 | 13 | 10 | 2 | 9 | 29 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.83 |