| SP | Koufax, S.Koufax, Sandy † # $ >> | 30 | 1965 | L | 97 | 40 | 40 | 27 | 9 | 3.19 | .290 | 1.20 | 8.3 | 2.5 | 8.1 | 299.1 | 277 | 107 | 106 | 21 | 82 | 268 | 6 | 0 | 0 | 1 | 28 | 7 | 4 | 3.01 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 39 | 39 | 14 | 16 | 5.47 | .335 | 1.49 | 9.2 | 4.2 | 8.3 | 247.0 | 253 | 154 | 150 | 36 | 116 | 228 | 1 | 0 | 0 | 0 | 17 | 4 | 7 | 4.51 |
| SP | Mathewson, C.Mathewson, Christy $$ >> | 28 | 1908 | R | 83 | 37 | 37 | 18 | 11 | 3.76 | .289 | 1.20 | 8.4 | 2.4 | 4.8 | 263.1 | 245 | 119 | 110 | 21 | 71 | 139 | 4 | 0 | 0 | 1 | 22 | 5 | 4 | 3.85 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 35 | 35 | 17 | 12 | 4.46 | .306 | 1.30 | 9.0 | 2.7 | 4.4 | 244.0 | 243 | 127 | 121 | 22 | 74 | 120 | 5 | 0 | 0 | 1 | 19 | 6 | 6 | 4.17 |
| RP | Adams, M.Adams, Mike $ >> | 31 | 2009 | R | 99 | 93 | 0 | 5 | 3 | 3.25 | .280 | 1.15 | 6.6 | 3.8 | 7.8 | 108.0 | 79 | 43 | 39 | 9 | 45 | 93 | 0 | 4 | 5 | 0 | 0 | 2 | 2 | 3.67 |
| RP | Saito, T.Saito, Takashi $ >> | 37 | 2007 | R | 92 | 60 | 0 | 9 | 3 | 3.38 | .262 | 1.07 | 6.5 | 3.1 | 8.7 | 66.2 | 48 | 25 | 25 | 10 | 23 | 64 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 4.08 |
| RP | Rivera, M.Rivera, Mariano $$ >> | 39 | 2008 | R | 85 | 33 | 0 | 0 | 2 | 2.29 | .248 | 0.99 | 7.5 | 1.5 | 6.7 | 35.1 | 29 | 9 | 9 | 1 | 6 | 26 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 2.40 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 84 | 18 | 0 | 2 | 0 | 2.66 | .330 | 1.48 | 9.0 | 4.5 | 9.9 | 20.1 | 20 | 6 | 6 | 3 | 10 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.25 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 78 | 25 | 0 | 0 | 1 | 4.97 | .351 | 1.55 | 10.9 | 3.1 | 8.7 | 29.0 | 35 | 16 | 16 | 5 | 10 | 28 | 0 | 2 | 0 | 0 | 0 | 2 | 1 | 4.55 |
| CL | Diaz, E.Diaz, Edwin † $ >> | 24 | 2018 | R | 88 | 65 | 0 | 1 | 3 | 3.03 | .264 | 1.04 | 7.0 | 2.4 | 10.1 | 59.1 | 46 | 21 | 20 | 6 | 16 | 66 | 0 | 53 | 5 | 0 | 0 | 2 | 3 | 3.00 |
| RP | Wilhelm, H.Wilhelm, Hoyt >> | 43 | 1965 | R | 69 | 20 | 0 | 1 | 2 | 4.57 | .295 | 1.23 | 7.7 | 3.5 | 6.4 | 41.1 | 35 | 21 | 21 | 7 | 16 | 29 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 5.05 |
| SP | Hendrix, C.Hendrix, Claude # >> | 25 | 1914 | R | 69 | 31 | 31 | 14 | 12 | 4.62 | .304 | 1.27 | 8.4 | 3.0 | 4.5 | 202.2 | 189 | 108 | 104 | 22 | 68 | 100 | 3 | 0 | 0 | 1 | 15 | 9 | 4 | 4.57 |