| SP | Arrieta, J.Arrieta, Jake † >> | 29 | 2015 | R | 93 | 20 | 20 | 12 | 5 | 3.33 | .283 | 1.15 | 7.8 | 2.5 | 8.5 | 146.0 | 127 | 57 | 54 | 10 | 41 | 138 | 0 | 0 | 0 | 0 | 15 | 5 | 3 | 2.95 |
| SP | Richard, J.Richard, J.R. † $ >> | 30 | 1980 | R | 90 | 19 | 19 | 14 | 2 | 3.43 | .298 | 1.21 | 7.1 | 3.8 | 7.6 | 131.1 | 103 | 51 | 50 | 12 | 56 | 111 | 2 | 0 | 0 | 0 | 15 | 8 | 4 | 3.96 |
| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 83 | 19 | 19 | 11 | 5 | 3.39 | .282 | 1.17 | 9.1 | 1.4 | 4.9 | 138.0 | 139 | 54 | 52 | 9 | 22 | 75 | 3 | 0 | 0 | 1 | 12 | 2 | 1 | 3.28 |
| SP | Ryan, N.Ryan, Nolan $$ >> | 44 | 1991 | R | 73 | 19 | 19 | 9 | 10 | 3.80 | .314 | 1.33 | 7.2 | 4.8 | 7.2 | 123.0 | 98 | 56 | 52 | 11 | 65 | 99 | 1 | 0 | 0 | 0 | 10 | 6 | 7 | 4.28 |
| SP | Fernandez, S.Fernandez, Sid >> | 23 | 1985 | L | 49 | 18 | 18 | 9 | 4 | 3.47 | .287 | 1.17 | 6.7 | 3.9 | 7.1 | 124.1 | 92 | 50 | 48 | 10 | 54 | 98 | 1 | 0 | 0 | 0 | 11 | 4 | 0 | 3.87 |
| RP | Harvey, B.Harvey, Bryan >> | 28 | 1991 | R | 66 | 25 | 0 | 3 | 0 | 4.10 | .262 | 1.06 | 6.6 | 3.1 | 7.3 | 26.1 | 19 | 12 | 12 | 5 | 9 | 21 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 4.92 |
| RP | Rincon, J.Rincon, Juan >> | 25 | 2004 | R | 44 | 14 | 0 | 1 | 0 | 3.38 | .259 | 1.05 | 6.2 | 3.5 | 9.7 | 13.1 | 9 | 5 | 5 | 2 | 5 | 14 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.00 |
| SP | Darvish, Y.Darvish, Yu >> | 26 | 2013 | R | 46 | 6 | 0 | 1 | 0 | 2.97 | .311 | 1.35 | 7.8 | 4.5 | 9.0 | 30.1 | 26 | 10 | 10 | 4 | 15 | 30 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4.23 |
| RP | Duchscherer, J.Duchscherer, Justin >> | 28 | 2005 | R | 22 | 20 | 0 | 1 | 1 | 4.12 | .337 | 1.47 | 9.9 | 3.8 | 7.6 | 19.2 | 21 | 9 | 9 | 2 | 8 | 16 | 0 | 1 | 0 | 0 | 0 | 1 | 2 | 4.11 |
| CL | Chapman, A.Chapman, Aroldis >> | 37 | 2025 | L | 96 | 40 | 0 | 0 | 3 | 3.47 | .288 | 1.21 | 6.3 | 4.8 | 8.5 | 36.1 | 25 | 15 | 14 | 4 | 19 | 34 | 0 | 29 | 2 | 0 | 0 | 0 | 4 | 4.14 |