| SP | Carpenter, C.Carpenter, Chris # >> | 29 | 2004 | R | 90 | 37 | 37 | 12 | 19 | 4.53 | .299 | 1.25 | 8.6 | 2.7 | 6.8 | 234.2 | 223 | 126 | 118 | 25 | 71 | 176 | 2 | 0 | 0 | 0 | 16 | 6 | 3 | 3.87 |
| SP | Radke, B.Radke, Brad † # >> | 32 | 2004 | R | 69 | 35 | 35 | 18 | 7 | 3.15 | .279 | 1.12 | 8.3 | 1.8 | 6.3 | 240.1 | 221 | 91 | 84 | 17 | 49 | 168 | 0 | 0 | 0 | 0 | 26 | 9 | 4 | 3.25 |
| SP | Buehrle, M.Buehrle, Mark >> | 25 | 2004 | L | 52 | 35 | 35 | 17 | 9 | 4.62 | .331 | 1.45 | 10.0 | 3.0 | 6.2 | 224.0 | 249 | 119 | 115 | 34 | 75 | 154 | 2 | 0 | 0 | 2 | 19 | 9 | 0 | 4.72 |
| SP | Halladay, R.Halladay, Roy >> | 27 | 2004 | R | 36 | 34 | 34 | 15 | 12 | 4.97 | .338 | 1.51 | 10.4 | 3.3 | 6.2 | 202.2 | 234 | 116 | 112 | 31 | 73 | 139 | 1 | 0 | 0 | 0 | 15 | 4 | 4 | 4.76 |
| SP | Washburn, J.Washburn, Jarrod >> | 30 | 2004 | L | 30 | 29 | 29 | 8 | 12 | 5.53 | .347 | 1.57 | 11.3 | 2.8 | 5.9 | 143.1 | 180 | 92 | 88 | 21 | 45 | 93 | 0 | 0 | 0 | 0 | 4 | 3 | 6 | 4.62 |
| RP | Guardado, E.Guardado, Eddie >> | 34 | 2004 | L | 91 | 96 | 0 | 3 | 5 | 3.08 | .277 | 1.13 | 6.6 | 3.6 | 8.9 | 128.2 | 94 | 44 | 44 | 13 | 51 | 126 | 0 | 11 | 7 | 0 | 0 | 3 | 0 | 3.62 |
| RP | Carrara, G.Carrara, Giovanni † >> | 36 | 2004 | R | 58 | 90 | 0 | 9 | 2 | 2.61 | .277 | 1.14 | 7.4 | 2.9 | 8.0 | 120.2 | 98 | 37 | 35 | 7 | 39 | 106 | 0 | 15 | 1 | 0 | 0 | 2 | 1 | 3.02 |
| RP | Shields, S.Shields, Scot >> | 29 | 2004 | R | 42 | 70 | 0 | 6 | 4 | 2.16 | .290 | 1.20 | 7.9 | 2.9 | 9.8 | 83.1 | 73 | 23 | 20 | 2 | 27 | 90 | 0 | 10 | 3 | 0 | 0 | 2 | 3 | 2.19 |
| RP | Witasick, J.Witasick, Jay >> | 32 | 2004 | R | 29 | 57 | 0 | 2 | 2 | 3.00 | .281 | 1.14 | 6.9 | 3.4 | 5.7 | 69.0 | 53 | 25 | 23 | 5 | 26 | 44 | 0 | 5 | 2 | 0 | 0 | 2 | 3 | 3.88 |
| RP | Alfonseca, A.Alfonseca, Antonio >> | 32 | 2004 | R | 18 | 45 | 0 | 3 | 4 | 5.98 | .347 | 1.58 | 11.8 | 2.6 | 7.8 | 52.2 | 68 | 40 | 35 | 11 | 15 | 45 | 0 | 4 | 2 | 0 | 0 | 1 | 5 | 4.94 |
| SP | Marquis, J.Marquis, Jason >> | 26 | 2004 | R | 15 | 19 | 3 | 3 | 1 | 2.89 | .307 | 1.33 | 9.0 | 3.1 | 5.7 | 43.2 | 43 | 16 | 14 | 3 | 15 | 27 | 0 | 3 | 0 | 0 | 2 | 0 | 0 | 3.70 |