| SP | Zambrano, C.Zambrano, Carlos # >> | 23 | 2004 | R | 91 | 33 | 33 | 6 | 10 | 3.94 | .294 | 1.21 | 8.2 | 2.7 | 8.1 | 210.1 | 191 | 98 | 92 | 21 | 63 | 189 | 1 | 0 | 0 | 1 | 21 | 9 | 5 | 3.53 |
| SP | Buehrle, M.Buehrle, Mark >> | 25 | 2004 | L | 52 | 32 | 32 | 5 | 21 | 4.88 | .318 | 1.36 | 10.3 | 2.0 | 5.7 | 214.0 | 244 | 121 | 116 | 29 | 47 | 136 | 2 | 0 | 0 | 0 | 14 | 9 | 0 | 4.28 |
| SP | Williams, W.Williams, Woody >> | 38 | 2004 | R | 44 | 32 | 32 | 9 | 12 | 4.93 | .339 | 1.50 | 9.3 | 4.2 | 5.3 | 189.2 | 196 | 113 | 104 | 22 | 88 | 111 | 0 | 0 | 0 | 0 | 17 | 8 | 13 | 4.86 |
| RP | Guardado, E.Guardado, Eddie >> | 34 | 2004 | L | 91 | 91 | 0 | 11 | 2 | 3.26 | .272 | 1.09 | 6.3 | 3.5 | 8.9 | 129.2 | 91 | 49 | 47 | 14 | 50 | 128 | 0 | 3 | 1 | 0 | 0 | 4 | 0 | 3.68 |
| RP | Almanzar, C.Almanzar, Carlos # >> | 31 | 2004 | R | 56 | 81 | 0 | 4 | 11 | 3.98 | .288 | 1.18 | 8.5 | 2.1 | 6.0 | 113.0 | 107 | 55 | 50 | 11 | 26 | 75 | 0 | 9 | 10 | 0 | 0 | 4 | 2 | 3.73 |
| RP | Shields, S.Shields, Scot >> | 29 | 2004 | R | 42 | 65 | 0 | 3 | 5 | 4.04 | .328 | 1.44 | 9.5 | 3.6 | 9.1 | 75.2 | 79 | 35 | 34 | 4 | 30 | 76 | 0 | 5 | 1 | 0 | 0 | 2 | 1 | 2.95 |
| RP | Witasick, J.Witasick, Jay >> | 32 | 2004 | R | 29 | 61 | 0 | 1 | 7 | 6.28 | .381 | 1.78 | 10.6 | 5.6 | 8.3 | 61.2 | 72 | 43 | 43 | 9 | 38 | 56 | 0 | 7 | 5 | 0 | 0 | 4 | 6 | 5.15 |
| RP | Alfonseca, A.Alfonseca, Antonio >> | 32 | 2004 | R | 18 | 42 | 0 | 1 | 3 | 6.26 | .395 | 1.91 | 13.5 | 3.7 | 6.8 | 46.0 | 69 | 39 | 32 | 5 | 19 | 35 | 0 | 3 | 3 | 0 | 0 | 2 | 5 | 4.26 |
| SP | Washburn, J.Washburn, Jarrod >> | 30 | 2004 | L | 30 | 1 | 0 | 0 | 0 | 18.00 | .438 | 2.33 | 9.0 | 12.0 | 12.0 | 3.0 | 3 | 6 | 6 | 2 | 4 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 13.00 |
| SP | Marquis, J.Marquis, Jason >> | 26 | 2004 | R | 15 | 27 | 0 | 4 | 4 | 3.53 | .287 | 1.21 | 9.8 | 1.3 | 6.7 | 35.2 | 38 | 14 | 14 | 7 | 5 | 26 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 4.54 |