| SP | Zambrano, C.Zambrano, Carlos # >> | 23 | 2004 | R | 91 | 7 | 7 | 3 | 3 | 5.36 | .300 | 1.24 | 7.3 | 3.9 | 7.5 | 42.0 | 34 | 26 | 25 | 8 | 18 | 35 | 0 | 0 | 0 | 0 | 4 | 2 | 1 | 5.24 |
| SP | Buehrle, M.Buehrle, Mark >> | 25 | 2004 | L | 52 | 7 | 7 | 2 | 3 | 5.21 | .300 | 1.22 | 8.6 | 2.5 | 5.3 | 46.2 | 44 | 27 | 27 | 6 | 13 | 27 | 1 | 0 | 0 | 1 | 2 | 3 | 0 | 4.57 |
| SP | Mulder, M.Mulder, Mark >> | 27 | 2004 | L | 38 | 6 | 6 | 3 | 0 | 3.03 | .318 | 1.35 | 8.7 | 3.6 | 6.7 | 35.2 | 34 | 13 | 12 | 3 | 14 | 26 | 0 | 0 | 0 | 0 | 4 | 2 | 1 | 4.00 |
| SP | Washburn, J.Washburn, Jarrod >> | 30 | 2004 | L | 30 | 6 | 6 | 1 | 5 | 4.73 | .336 | 1.52 | 11.0 | 2.8 | 4.8 | 32.1 | 39 | 21 | 17 | 4 | 10 | 17 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 4.50 |
| RP | Gonzalez, M.Gonzalez, Mike >> | 26 | 2004 | L | 92 | 16 | 0 | 2 | 0 | 2.33 | .243 | 0.93 | 6.3 | 2.0 | 9.7 | 27.0 | 19 | 7 | 7 | 1 | 6 | 29 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 2.11 |
| RP | Almanzar, C.Almanzar, Carlos >> | 31 | 2004 | R | 56 | 18 | 0 | 0 | 0 | 3.86 | .293 | 1.24 | 9.8 | 1.6 | 5.5 | 23.1 | 25 | 10 | 10 | 3 | 4 | 14 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 4.00 |
| RP | Shields, S.Shields, Scot >> | 29 | 2004 | R | 42 | 12 | 0 | 2 | 0 | 5.11 | .327 | 1.38 | 7.5 | 5.3 | 11.3 | 12.1 | 10 | 7 | 7 | 2 | 7 | 15 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 4.67 |
| RP | Witasick, J.Witasick, Jay >> | 32 | 2004 | R | 29 | 7 | 0 | 1 | 0 | 6.75 | .400 | 2.00 | 10.1 | 7.9 | 7.9 | 8.0 | 9 | 6 | 6 | 2 | 7 | 7 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 7.13 |
| RP | Alfonseca, A.Alfonseca, Antonio >> | 32 | 2004 | R | 18 | 9 | 0 | 0 | 1 | 3.18 | .261 | 1.06 | 7.4 | 2.5 | 5.7 | 11.1 | 9 | 5 | 4 | 0 | 3 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.55 |
| SP | Garland, J.Garland, Jon >> | 25 | 2004 | R | 28 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Marquis, J.Marquis, Jason >> | 26 | 2004 | R | 15 | 4 | 0 | 0 | 0 | 1.69 | .273 | 1.13 | 3.6 | 7.2 | 3.6 | 5.1 | 2 | 1 | 1 | 0 | 4 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.60 |