| SP | Zambrano, C.Zambrano, Carlos † >> | 23 | 2004 | R | 91 | 34 | 34 | 12 | 12 | 2.25 | .268 | 1.05 | 6.0 | 3.5 | 6.4 | 231.2 | 155 | 60 | 58 | 15 | 89 | 165 | 1 | 0 | 0 | 1 | 26 | 11 | 4 | 3.71 |
| SP | Lackey, J.Lackey, John # >> | 26 | 2004 | R | 20 | 31 | 31 | 8 | 14 | 5.04 | .330 | 1.43 | 9.7 | 3.2 | 6.4 | 184.0 | 198 | 106 | 103 | 32 | 65 | 130 | 0 | 0 | 0 | 0 | 15 | 9 | 2 | 5.05 |
| RP | Gonzalez, M.Gonzalez, Mike >> | 26 | 2004 | L | 92 | 98 | 0 | 6 | 4 | 3.77 | .285 | 1.17 | 7.9 | 2.6 | 9.2 | 150.1 | 132 | 69 | 63 | 21 | 44 | 154 | 0 | 8 | 8 | 0 | 0 | 4 | 5 | 3.73 |
| RP | Osuna, A.Osuna, Antonio >> | 31 | 2004 | R | 62 | 94 | 0 | 6 | 5 | 3.90 | .316 | 1.35 | 8.3 | 3.9 | 9.1 | 120.0 | 110 | 54 | 52 | 12 | 52 | 121 | 0 | 13 | 6 | 0 | 0 | 4 | 0 | 3.68 |
| RP | Burba, D.Burba, Dave # >> | 38 | 2004 | R | 45 | 79 | 0 | 8 | 5 | 5.49 | .313 | 1.33 | 9.4 | 2.7 | 5.9 | 96.2 | 100 | 63 | 59 | 23 | 29 | 63 | 0 | 7 | 6 | 0 | 0 | 3 | 0 | 5.80 |
| RP | Betancourt, R.Betancourt, Rafael >> | 29 | 2004 | R | 23 | 54 | 0 | 1 | 6 | 4.13 | .325 | 1.38 | 9.5 | 2.9 | 8.1 | 72.0 | 76 | 38 | 33 | 11 | 23 | 65 | 0 | 2 | 2 | 0 | 0 | 5 | 3 | 4.35 |