| SP | Burnett, A.Burnett, A.J. # >> | 27 | 2004 | R | 93 | 12 | 12 | 5 | 6 | 3.01 | .284 | 1.13 | 7.3 | 2.9 | 8.1 | 80.2 | 65 | 27 | 27 | 7 | 26 | 72 | 1 | 0 | 0 | 1 | 8 | 5 | 2 | 3.50 |
| SP | Buehrle, M.Buehrle, Mark >> | 25 | 2004 | L | 52 | 12 | 12 | 5 | 4 | 4.98 | .322 | 1.36 | 9.3 | 3.0 | 4.7 | 81.1 | 84 | 46 | 45 | 10 | 27 | 42 | 1 | 0 | 0 | 0 | 6 | 5 | 0 | 4.75 |
| SP | Colon, B.Colon, Bartolo >> | 31 | 2004 | R | 37 | 12 | 12 | 6 | 4 | 3.89 | .302 | 1.27 | 8.0 | 3.4 | 5.5 | 74.0 | 66 | 32 | 32 | 10 | 28 | 45 | 0 | 0 | 0 | 0 | 7 | 2 | 0 | 4.76 |
| SP | Suppan, J.Suppan, Jeff >> | 29 | 2004 | R | 32 | 12 | 12 | 1 | 7 | 7.53 | .360 | 1.64 | 11.0 | 3.9 | 6.0 | 63.1 | 77 | 53 | 53 | 14 | 27 | 42 | 0 | 0 | 0 | 0 | 3 | 3 | 1 | 5.98 |
| RP | Gonzalez, M.Gonzalez, Mike >> | 26 | 2004 | L | 92 | 32 | 0 | 2 | 2 | 4.82 | .358 | 1.67 | 12.7 | 2.5 | 7.4 | 46.2 | 65 | 26 | 25 | 6 | 13 | 38 | 0 | 5 | 4 | 0 | 0 | 0 | 8 | 3.89 |
| RP | Duchscherer, J.Duchscherer, Justin >> | 27 | 2004 | R | 55 | 30 | 0 | 0 | 1 | 4.10 | .309 | 1.31 | 9.7 | 2.2 | 6.6 | 37.1 | 40 | 17 | 17 | 6 | 9 | 27 | 0 | 1 | 2 | 0 | 0 | 1 | 1 | 4.46 |
| RP | Harikkala, T.Harikkala, Tim >> | 33 | 2004 | R | 43 | 23 | 0 | 0 | 0 | 1.95 | .265 | 1.08 | 6.7 | 3.3 | 4.0 | 27.2 | 20 | 7 | 6 | 1 | 10 | 12 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 3.70 |
| RP | Stanton, M.Stanton, Mike >> | 37 | 2004 | L | 33 | 20 | 0 | 2 | 1 | 4.44 | .347 | 1.56 | 9.3 | 4.8 | 6.6 | 26.1 | 27 | 13 | 13 | 4 | 14 | 19 | 0 | 3 | 0 | 0 | 0 | 1 | 0 | 5.27 |
| RP | Betancourt, R.Betancourt, Rafael >> | 29 | 2004 | R | 23 | 23 | 0 | 3 | 1 | 4.10 | .325 | 1.29 | 8.0 | 3.8 | 9.0 | 26.1 | 23 | 12 | 12 | 5 | 11 | 26 | 0 | 2 | 2 | 0 | 0 | 4 | 0 | 5.23 |
| SP | Willis, D.Willis, Dontrelle >> | 22 | 2004 | L | 27 | 9 | 0 | 1 | 1 | 2.92 | .327 | 1.38 | 9.8 | 3.0 | 7.5 | 12.1 | 13 | 4 | 4 | 2 | 4 | 10 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 4.75 |