| SP | Clemens, R.Clemens, Roger >> | 42 | 2004 | R | 95 | 19 | 19 | 7 | 8 | 4.37 | .327 | 1.41 | 8.7 | 4.0 | 8.8 | 107.0 | 103 | 63 | 52 | 8 | 48 | 105 | 0 | 0 | 0 | 0 | 10 | 5 | 1 | 3.50 |
| SP | Maddux, G.Maddux, Greg >> | 38 | 2004 | R | 71 | 19 | 18 | 1 | 11 | 9.97 | .394 | 1.92 | 15.0 | 2.4 | 5.4 | 65.0 | 108 | 72 | 72 | 17 | 17 | 39 | 0 | 0 | 0 | 0 | 3 | 2 | 4 | 6.08 |
| SP | Harden, R.Harden, Rich >> | 23 | 2004 | R | 63 | 19 | 18 | 6 | 5 | 6.12 | .369 | 1.70 | 11.4 | 3.9 | 7.4 | 85.1 | 108 | 59 | 58 | 13 | 37 | 70 | 0 | 0 | 0 | 0 | 7 | 5 | 2 | 4.82 |
| CL | Rincon, J.Rincon, Juan † >> | 25 | 2004 | R | 94 | 56 | 0 | 5 | 0 | 3.86 | .338 | 1.48 | 8.9 | 4.6 | 9.6 | 65.1 | 64 | 31 | 28 | 2 | 33 | 69 | 0 | 15 | 3 | 0 | 0 | 3 | 1 | 2.94 |
| SU | Linebrink, S.Linebrink, Scott >> | 28 | 2004 | R | 89 | 65 | 0 | 0 | 2 | 3.80 | .315 | 1.32 | 8.1 | 3.8 | 6.7 | 71.0 | 64 | 32 | 30 | 5 | 30 | 53 | 0 | 3 | 3 | 0 | 0 | 4 | 3 | 3.86 |
| RP | Miller, M.Miller, Matt >> | 33 | 2004 | R | 77 | 60 | 0 | 3 | 3 | 3.47 | .331 | 1.43 | 8.5 | 4.5 | 8.5 | 72.2 | 68 | 29 | 28 | 3 | 36 | 68 | 0 | 0 | 2 | 0 | 0 | 4 | 2 | 3.32 |
| RP | Marte, D.Marte, Damaso >> | 29 | 2004 | L | 68 | 65 | 0 | 5 | 3 | 5.60 | .321 | 1.38 | 7.0 | 5.5 | 7.3 | 80.1 | 62 | 58 | 50 | 11 | 49 | 65 | 0 | 2 | 4 | 0 | 0 | 3 | 5 | 5.11 |
| RP | Duchscherer, J.Duchscherer, Justin >> | 27 | 2004 | R | 55 | 53 | 0 | 4 | 3 | 4.28 | .309 | 1.32 | 9.2 | 2.7 | 5.8 | 73.2 | 75 | 38 | 35 | 9 | 22 | 47 | 0 | 0 | 1 | 0 | 0 | 2 | 1 | 4.30 |