| SP | Santana, J.Santana, Johan † >> | 25 | 2004 | L | 99 | 27 | 27 | 14 | 4 | 2.74 | .274 | 1.08 | 7.3 | 2.4 | 9.2 | 190.1 | 154 | 66 | 58 | 19 | 51 | 194 | 2 | 0 | 0 | 2 | 19 | 10 | 1 | 3.22 |
| SP | Buehrle, M.Buehrle, Mark # >> | 25 | 2004 | L | 52 | 26 | 26 | 9 | 7 | 5.04 | .343 | 1.55 | 11.0 | 2.9 | 6.9 | 157.0 | 192 | 98 | 88 | 31 | 51 | 120 | 0 | 0 | 0 | 0 | 13 | 3 | 0 | 5.07 |
| CL | Gagne, E.Gagne, Eric † >> | 28 | 2004 | R | 97 | 53 | 0 | 3 | 6 | 2.60 | .281 | 1.15 | 8.1 | 2.3 | 9.7 | 52.0 | 47 | 15 | 15 | 4 | 13 | 56 | 0 | 36 | 3 | 0 | 0 | 1 | 0 | 2.65 |
| SU | Hoffman, T.Hoffman, Trevor >> | 37 | 2004 | R | 89 | 42 | 0 | 5 | 3 | 4.56 | .294 | 1.20 | 8.6 | 2.3 | 8.4 | 47.1 | 45 | 24 | 24 | 5 | 12 | 44 | 0 | 0 | 6 | 0 | 0 | 2 | 4 | 3.40 |
| RP | Smoltz, J.Smoltz, John >> | 37 | 2004 | R | 75 | 61 | 0 | 7 | 2 | 3.58 | .303 | 1.28 | 10.1 | 1.5 | 9.3 | 55.1 | 62 | 23 | 22 | 6 | 9 | 57 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 2.89 |
| RP | Cordero, F.Cordero, Francisco >> | 29 | 2004 | R | 56 | 43 | 0 | 4 | 0 | 4.50 | .337 | 1.47 | 6.3 | 7.0 | 9.0 | 36.0 | 25 | 18 | 18 | 6 | 28 | 36 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 5.67 |
| RP | Miller, T.Miller, Trever >> | 31 | 2004 | L | 35 | 48 | 0 | 1 | 1 | 3.76 | .286 | 1.17 | 7.6 | 3.1 | 5.4 | 38.1 | 32 | 16 | 16 | 5 | 13 | 23 | 0 | 0 | 2 | 0 | 0 | 1 | 2 | 4.61 |
| RP | Marte, D.Marte, Damaso >> | 29 | 2004 | L | 68 | 46 | 0 | 4 | 0 | 5.08 | .364 | 1.67 | 10.2 | 4.8 | 7.2 | 39.0 | 44 | 22 | 22 | 6 | 21 | 31 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 5.18 |