| SP | Johnson, R.Johnson, Randy † >> | 41 | 2004 | L | 100 | 27 | 27 | 14 | 7 | 2.49 | .266 | 1.05 | 6.9 | 2.5 | 9.4 | 206.0 | 159 | 62 | 57 | 17 | 58 | 216 | 8 | 0 | 0 | 2 | 21 | 7 | 5 | 2.92 |
| SP | Maddux, G.Maddux, Greg >> | 38 | 2004 | R | 71 | 26 | 26 | 9 | 9 | 5.46 | .338 | 1.52 | 10.8 | 2.9 | 6.0 | 148.1 | 178 | 95 | 90 | 23 | 47 | 99 | 0 | 0 | 0 | 0 | 8 | 2 | 4 | 4.68 |
| RP | Wagner, B.Wagner, Billy >> | 33 | 2004 | L | 100 | 68 | 0 | 5 | 5 | 3.63 | .289 | 1.21 | 8.6 | 2.3 | 10.0 | 104.0 | 99 | 45 | 42 | 12 | 27 | 116 | 0 | 4 | 1 | 0 | 0 | 1 | 1 | 3.08 |
| RP | Isringhausen, J.Isringhausen, Jason >> | 32 | 2004 | R | 86 | 70 | 0 | 7 | 3 | 5.46 | .327 | 1.41 | 9.1 | 3.6 | 6.2 | 94.0 | 95 | 65 | 57 | 23 | 38 | 65 | 0 | 7 | 7 | 0 | 0 | 4 | 2 | 6.14 |
| RP | Rivera, M.Rivera, Mariano >> | 35 | 2004 | R | 79 | 64 | 0 | 5 | 2 | 2.94 | .273 | 1.11 | 7.1 | 3.0 | 7.4 | 88.2 | 69 | 29 | 29 | 7 | 29 | 72 | 0 | 9 | 2 | 0 | 0 | 2 | 0 | 3.45 |
| RP | Tavarez, J.Tavarez, Julian >> | 31 | 2004 | R | 59 | 43 | 0 | 4 | 4 | 5.70 | .396 | 1.94 | 11.3 | 6.3 | 7.9 | 47.1 | 59 | 31 | 30 | 3 | 33 | 41 | 0 | 2 | 3 | 0 | 0 | 1 | 0 | 4.26 |
| SP | Mussina, M.Mussina, Mike >> | 36 | 2004 | R | 42 | 1 | 0 | 0 | 0 | 0.00 | .000 | 0.00 | - | - | - | 0.1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |