| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 29 | 29 | 7 | 14 | 5.77 | .332 | 1.45 | 9.7 | 3.4 | 10.2 | 174.2 | 188 | 119 | 112 | 33 | 65 | 197 | 0 | 0 | 0 | 0 | 10 | 8 | 2 | 4.46 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 95 | 28 | 28 | 13 | 11 | 3.90 | .298 | 1.25 | 8.4 | 2.8 | 9.2 | 201.0 | 188 | 97 | 87 | 22 | 63 | 205 | 3 | 0 | 0 | 2 | 17 | 5 | 8 | 3.40 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 89 | 27 | 27 | 14 | 10 | 3.76 | .295 | 1.22 | 8.2 | 2.7 | 9.1 | 191.2 | 175 | 85 | 80 | 28 | 58 | 193 | 6 | 0 | 0 | 2 | 14 | 8 | 2 | 3.92 |
| SP | Perry, G.Perry, Gaylord >> | 34 | 1972 | R | 67 | 27 | 27 | 12 | 8 | 4.58 | .315 | 1.35 | 9.1 | 3.1 | 6.5 | 198.1 | 200 | 113 | 101 | 23 | 68 | 143 | 8 | 0 | 0 | 2 | 11 | 6 | 10 | 4.19 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 91 | 72 | 0 | 3 | 3 | 4.24 | .320 | 1.34 | 7.8 | 4.3 | 9.3 | 91.1 | 79 | 48 | 43 | 11 | 43 | 94 | 0 | 5 | 3 | 0 | 0 | 7 | 0 | 4.15 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 78 | 41 | 0 | 2 | 6 | 5.77 | .350 | 1.62 | 9.7 | 4.8 | 8.5 | 39.0 | 42 | 32 | 25 | 12 | 21 | 37 | 0 | 1 | 3 | 0 | 0 | 0 | 4 | 6.72 |
| RP | Betancourt, R.Betancourt, Rafael # >> | 32 | 2007 | R | 75 | 43 | 0 | 2 | 1 | 4.29 | .301 | 1.23 | 9.5 | 1.6 | 9.4 | 50.1 | 53 | 25 | 24 | 11 | 9 | 52 | 0 | 2 | 1 | 0 | 0 | 3 | 0 | 4.50 |
| SP | Halladay, R.Halladay, Roy >> | 28 | 2005 | R | 58 | 13 | 1 | 0 | 5 | 7.85 | .415 | 2.07 | 13.0 | 6.0 | 9.5 | 18.1 | 26 | 19 | 16 | 5 | 12 | 19 | 0 | 2 | 0 | 0 | 0 | 1 | 1 | 6.67 |