| SP | Greinke, Z.Greinke, Zack >> | 32 | 2015 | R | 93 | 29 | 29 | 12 | 9 | 3.32 | .268 | 1.07 | 7.2 | 2.5 | 6.6 | 208.2 | 166 | 78 | 77 | 23 | 58 | 153 | 6 | 0 | 0 | 1 | 20 | 5 | 2 | 3.88 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 90 | 29 | 29 | 14 | 8 | 3.61 | .271 | 1.07 | 6.9 | 2.7 | 5.7 | 214.1 | 165 | 89 | 86 | 27 | 64 | 135 | 5 | 0 | 0 | 1 | 18 | 10 | 2 | 4.42 |
| SP | Sutton, D.Sutton, Don † >> | 27 | 1972 | R | 86 | 28 | 28 | 15 | 8 | 3.25 | .287 | 1.16 | 8.1 | 2.3 | 5.9 | 196.1 | 177 | 71 | 71 | 16 | 50 | 128 | 7 | 0 | 0 | 2 | 20 | 10 | 3 | 3.67 |
| SP | McClanahan, S.McClanahan, Shane >> | 25 | 2022 | L | 89 | 28 | 28 | 12 | 10 | 5.24 | .313 | 1.34 | 9.1 | 3.0 | 9.3 | 168.1 | 169 | 102 | 98 | 36 | 56 | 174 | 0 | 0 | 0 | 0 | 11 | 5 | 9 | 4.80 |
| SP | Seaver, T.Seaver, Tom # >> | 27 | 1971 | R | 81 | 26 | 26 | 18 | 6 | 3.74 | .266 | 1.09 | 7.6 | 2.2 | 8.6 | 178.0 | 150 | 76 | 74 | 19 | 44 | 171 | 7 | 0 | 0 | 1 | 18 | 0 | 1 | 3.21 |
| CL | Soriano, R.Soriano, Rafael † >> | 24 | 2003 | R | 83 | 59 | 0 | 3 | 5 | 1.75 | .236 | 0.92 | 5.5 | 3.0 | 9.0 | 61.2 | 37 | 13 | 12 | 5 | 20 | 61 | 0 | 40 | 2 | 0 | 0 | 0 | 0 | 3.05 |
| SU | Percival, T.Percival, Troy >> | 26 | 1995 | R | 80 | 45 | 0 | 1 | 2 | 2.30 | .244 | 0.95 | 4.8 | 3.8 | 9.7 | 54.2 | 29 | 14 | 14 | 6 | 23 | 58 | 0 | 6 | 2 | 0 | 0 | 1 | 3 | 3.63 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 69 | 58 | 0 | 2 | 1 | 4.36 | .297 | 1.25 | 7.7 | 3.5 | 10.4 | 64.0 | 55 | 31 | 31 | 8 | 25 | 74 | 0 | 1 | 2 | 0 | 0 | 1 | 2 | 3.53 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 66 | 23 | 0 | 4 | 1 | 4.66 | .389 | 1.86 | 10.4 | 6.6 | 11.8 | 19.1 | 22 | 13 | 10 | 3 | 14 | 25 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.79 |
| RP | Sutter, B.Sutter, Bruce >> | 24 | 1977 | R | 64 | 26 | 0 | 1 | 2 | 1.16 | .238 | 0.90 | 6.4 | 1.7 | 7.3 | 31.0 | 22 | 4 | 4 | 2 | 6 | 25 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 2.90 |
| SP | Lincecum, T.Lincecum, Tim >> | 25 | 2009 | R | 57 | 14 | 2 | 3 | 0 | 2.71 | .266 | 1.06 | 6.3 | 3.3 | 8.2 | 66.1 | 46 | 20 | 20 | 5 | 24 | 60 | 0 | 0 | 0 | 0 | 1 | 2 | 2 | 3.35 |