| SP | Richard, J.Richard, J.R. >> | 30 | 1980 | R | 94 | 29 | 29 | 11 | 9 | 4.18 | .327 | 1.42 | 8.4 | 4.4 | 9.3 | 189.2 | 177 | 104 | 88 | 15 | 92 | 196 | 1 | 0 | 0 | 1 | 14 | 8 | 3 | 3.54 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 82 | 28 | 28 | 11 | 7 | 4.05 | .290 | 1.18 | 7.2 | 3.5 | 8.0 | 184.1 | 147 | 85 | 83 | 24 | 71 | 164 | 1 | 0 | 0 | 1 | 15 | 8 | 3 | 4.20 |
| SP | Carlton, S.Carlton, Steve >> | 28 | 1972 | L | 69 | 25 | 25 | 14 | 5 | 4.60 | .321 | 1.38 | 9.6 | 2.8 | 7.3 | 182.0 | 195 | 94 | 93 | 31 | 56 | 147 | 6 | 0 | 0 | 1 | 12 | 7 | 2 | 4.64 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 84 | 72 | 0 | 4 | 1 | 2.62 | .264 | 1.00 | 7.9 | 1.2 | 8.1 | 68.2 | 60 | 22 | 20 | 4 | 9 | 61 | 0 | 1 | 0 | 0 | 0 | 5 | 0 | 2.59 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 76 | 68 | 0 | 4 | 0 | 2.27 | .214 | 0.80 | 4.8 | 2.5 | 8.4 | 47.2 | 25 | 13 | 12 | 5 | 13 | 44 | 0 | 1 | 0 | 0 | 0 | 1 | 6 | 3.40 |
| CL | Hoffman, T.Hoffman, Trevor † >> | 31 | 1998 | R | 72 | 58 | 0 | 3 | 5 | 2.39 | .261 | 1.03 | 5.9 | 3.5 | 8.0 | 60.1 | 39 | 16 | 16 | 5 | 23 | 53 | 0 | 36 | 4 | 0 | 0 | 2 | 3 | 3.57 |
| RP | Zimmerman, J.Zimmerman, Jeff # >> | 27 | 1999 | R | 67 | 48 | 0 | 3 | 5 | 5.53 | .298 | 1.28 | 9.0 | 2.6 | 6.2 | 42.1 | 42 | 26 | 26 | 9 | 12 | 29 | 0 | 2 | 3 | 0 | 0 | 0 | 0 | 5.26 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 63 | 28 | 0 | 4 | 1 | 1.59 | .267 | 1.06 | 3.2 | 6.4 | 9.0 | 28.1 | 10 | 5 | 5 | 2 | 20 | 28 | 0 | 3 | 2 | 0 | 0 | 1 | 2 | 4.18 |
| RP | Harvey, B.Harvey, Bryan >> | 28 | 1991 | R | 62 | 13 | 0 | 0 | 1 | 4.26 | .309 | 1.34 | 9.8 | 3.0 | 10.5 | 12.2 | 13 | 6 | 6 | 1 | 4 | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.75 |
| SP | Darvish, Y.Darvish, Yu >> | 26 | 2013 | R | 55 | 8 | 2 | 2 | 2 | 3.86 | .274 | 1.13 | 8.2 | 2.3 | 10.1 | 32.2 | 29 | 18 | 14 | 7 | 8 | 36 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 4.34 |