| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 17 | 17 | 4 | 7 | 3.10 | .265 | 1.05 | 7.5 | 2.0 | 9.6 | 119.0 | 99 | 43 | 41 | 13 | 26 | 127 | 1 | 0 | 0 | 0 | 12 | 4 | 0 | 3.04 |
| SP | Fernandez, J.Fernandez, Jose † >> | 21 | 2013 | R | 83 | 16 | 16 | 9 | 3 | 2.84 | .271 | 1.10 | 6.6 | 3.4 | 10.3 | 107.2 | 78 | 38 | 34 | 11 | 40 | 122 | 3 | 0 | 0 | 1 | 12 | 2 | 0 | 3.23 |
| SP | Fernandez, S.Fernandez, Sid † >> | 23 | 1985 | L | 53 | 16 | 16 | 11 | 1 | 2.94 | .262 | 1.06 | 5.7 | 3.9 | 9.4 | 113.1 | 71 | 39 | 37 | 10 | 49 | 118 | 1 | 0 | 0 | 0 | 11 | 1 | 1 | 3.39 |
| SP | Darvish, Y.Darvish, Yu >> | 26 | 2013 | R | 57 | 16 | 16 | 7 | 4 | 3.14 | .270 | 1.08 | 5.8 | 3.9 | 10.3 | 114.2 | 74 | 46 | 40 | 17 | 50 | 131 | 2 | 0 | 0 | 1 | 9 | 3 | 3 | 4.04 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 75 | 49 | 0 | 4 | 3 | 3.12 | .281 | 1.15 | 5.4 | 5.0 | 11.4 | 52.0 | 31 | 20 | 18 | 9 | 29 | 66 | 0 | 1 | 4 | 0 | 0 | 1 | 0 | 4.44 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 73 | 42 | 0 | 1 | 6 | 5.17 | .327 | 1.43 | 8.8 | 4.3 | 13.0 | 38.1 | 37 | 22 | 22 | 7 | 18 | 55 | 0 | 5 | 2 | 0 | 0 | 1 | 5 | 4.00 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 72 | 25 | 0 | 4 | 2 | 1.82 | .246 | 0.98 | 5.9 | 3.1 | 7.4 | 29.2 | 19 | 6 | 6 | 1 | 10 | 24 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 2.83 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 70 | 25 | 0 | 2 | 1 | 0.96 | .176 | 0.64 | 4.5 | 1.3 | 7.4 | 28.0 | 14 | 3 | 3 | 2 | 4 | 23 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 2.71 |
| CL | Marmol, C.Marmol, Carlos † >> | 26 | 2008 | R | 67 | 32 | 0 | 1 | 1 | 2.51 | .297 | 1.24 | 5.6 | 5.6 | 9.6 | 32.1 | 20 | 10 | 9 | 2 | 20 | 34 | 0 | 15 | 3 | 0 | 0 | 1 | 0 | 3.66 |