| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 17 | 17 | 7 | 4 | 4.43 | .311 | 1.32 | 7.7 | 4.2 | 7.7 | 107.2 | 92 | 55 | 53 | 17 | 50 | 91 | 1 | 0 | 0 | 0 | 8 | 4 | 4 | 4.88 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 85 | 18 | 18 | 7 | 9 | 4.34 | .316 | 1.35 | 8.6 | 3.6 | 7.4 | 120.1 | 114 | 62 | 58 | 17 | 48 | 99 | 2 | 0 | 0 | 0 | 10 | 5 | 3 | 4.52 |
| SP | Cueto, J.Cueto, Johnny >> | 28 | 2014 | R | 75 | 15 | 15 | 4 | 7 | 5.79 | .338 | 1.51 | 8.9 | 4.7 | 7.2 | 93.1 | 92 | 60 | 60 | 14 | 49 | 74 | 1 | 0 | 0 | 0 | 6 | 2 | 1 | 5.01 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 47 | 0 | 7 | 1 | 4.88 | .279 | 1.14 | 7.2 | 3.2 | 8.5 | 51.2 | 41 | 29 | 28 | 11 | 18 | 48 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 5.04 |
| SU | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 39 | 0 | 0 | 0 | 4.29 | .327 | 1.40 | 7.5 | 5.4 | 9.5 | 35.2 | 29 | 17 | 17 | 5 | 21 | 37 | 0 | 5 | 4 | 0 | 0 | 2 | 0 | 4.71 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 83 | 35 | 0 | 0 | 1 | 4.38 | .339 | 1.51 | 8.5 | 5.1 | 8.8 | 39.0 | 37 | 19 | 19 | 2 | 22 | 38 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 3.49 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 28 | 0 | 2 | 2 | 4.73 | .287 | 1.18 | 6.8 | 3.9 | 9.8 | 32.1 | 24 | 17 | 17 | 7 | 14 | 35 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 5.06 |