| SP | Koufax, S.Koufax, Sandy † >> | 30 | 1965 | L | 97 | 34 | 34 | 21 | 10 | 3.44 | .291 | 1.21 | 7.8 | 3.0 | 7.9 | 256.1 | 223 | 99 | 98 | 24 | 86 | 226 | 14 | 0 | 0 | 3 | 21 | 6 | 5 | 3.53 |
| SP | Alexander, P.Alexander, Pete † $ >> | 28 | 1915 | R | 88 | 33 | 33 | 17 | 13 | 3.34 | .280 | 1.16 | 7.9 | 2.5 | 4.8 | 261.0 | 229 | 99 | 97 | 22 | 73 | 138 | 17 | 0 | 0 | 3 | 22 | 2 | 5 | 3.90 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 32 | 32 | 16 | 13 | 3.77 | .276 | 1.14 | 8.1 | 2.2 | 5.3 | 234.0 | 210 | 100 | 98 | 18 | 56 | 139 | 13 | 0 | 0 | 5 | 16 | 2 | 3 | 3.56 |
| SP | Johnson, R.Johnson, Randy # >> | 41 | 2004 | L | 83 | 31 | 31 | 15 | 9 | 4.41 | .289 | 1.19 | 8.3 | 2.5 | 7.8 | 210.1 | 193 | 104 | 103 | 25 | 58 | 181 | 5 | 0 | 0 | 1 | 16 | 5 | 5 | 3.72 |
| RP | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 95 | 66 | 0 | 2 | 7 | 3.63 | .265 | 1.06 | 5.8 | 3.8 | 9.3 | 79.1 | 51 | 32 | 32 | 8 | 33 | 82 | 0 | 8 | 2 | 0 | 0 | 2 | 2 | 3.57 |
| RP | Eckersley, D.Eckersley, Dennis $ >> | 36 | 1990 | R | 88 | 37 | 0 | 3 | 1 | 4.15 | .278 | 1.10 | 8.5 | 1.6 | 9.3 | 34.2 | 32 | 16 | 16 | 5 | 6 | 35 | 0 | 6 | 1 | 0 | 0 | 2 | 0 | 3.56 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 13 | 0 | 1 | 1 | 5.56 | .382 | 1.85 | 16.4 | 0.8 | 6.5 | 11.1 | 20 | 10 | 7 | 2 | 1 | 8 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 4.18 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 9 | 0 | 1 | 0 | 4.91 | .214 | 0.82 | 5.8 | 1.9 | 5.1 | 14.2 | 9 | 8 | 8 | 3 | 3 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.29 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 12 | 0 | 0 | 0 | 3.24 | .219 | 0.84 | 5.1 | 2.8 | 4.5 | 16.2 | 9 | 6 | 6 | 4 | 5 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.19 |