| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 7 | 7 | 2 | 4 | 4.57 | .287 | 1.16 | 6.1 | 4.4 | 6.8 | 41.1 | 28 | 22 | 21 | 3 | 20 | 31 | 1 | 0 | 0 | 0 | 3 | 2 | 2 | 4.05 |
| SP | McNally, D.McNally, Dave # >> | 26 | 1968 | L | 96 | 7 | 7 | 2 | 3 | 5.17 | .338 | 1.47 | 10.5 | 2.7 | 5.6 | 47.0 | 55 | 27 | 27 | 6 | 14 | 29 | 1 | 0 | 0 | 1 | 2 | 3 | 0 | 4.51 |
| SP | Cueto, J.Cueto, Johnny >> | 28 | 2014 | R | 75 | 7 | 7 | 4 | 1 | 4.32 | .346 | 1.54 | 10.5 | 3.5 | 7.2 | 41.2 | 48 | 21 | 20 | 5 | 16 | 33 | 0 | 0 | 0 | 0 | 2 | 2 | 0 | 4.29 |
| SP | Cicotte, E.Cicotte, Eddie # >> | 33 | 1917 | R | 73 | 7 | 7 | 4 | 2 | 3.55 | .255 | 0.99 | 7.2 | 1.8 | 4.2 | 45.2 | 36 | 20 | 18 | 2 | 9 | 21 | 0 | 0 | 0 | 0 | 5 | 2 | 1 | 3.38 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 7 | 5 | 1 | 3 | 2.91 | .255 | 0.97 | 5.8 | 2.9 | 6.9 | 34.0 | 22 | 11 | 11 | 2 | 11 | 26 | 0 | 0 | 0 | 0 | 3 | 2 | 0 | 3.38 |
| RP | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 88 | 19 | 0 | 0 | 2 | 3.20 | .322 | 1.32 | 8.5 | 3.8 | 12.3 | 19.2 | 18 | 7 | 7 | 1 | 8 | 26 | 0 | 1 | 1 | 0 | 0 | 2 | 1 | 2.53 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 15 | 0 | 1 | 2 | 1.99 | .244 | 0.97 | 7.8 | 1.2 | 8.2 | 22.2 | 19 | 5 | 5 | 0 | 3 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.59 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 17 | 0 | 0 | 2 | 7.56 | .367 | 1.74 | 10.1 | 6.2 | 9.0 | 16.2 | 18 | 14 | 14 | 3 | 11 | 16 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 5.50 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 67 | 11 | 0 | 0 | 1 | 3.00 | .333 | 1.33 | 9.8 | 2.3 | 5.3 | 12.0 | 13 | 6 | 4 | 2 | 3 | 7 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 5.25 |
| SU | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 84 | 9 | 0 | 0 | 0 | 2.19 | .245 | 0.97 | 7.5 | 1.5 | 9.0 | 12.1 | 10 | 3 | 3 | 1 | 2 | 12 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 2.58 |
| CL | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 8 | 0 | 0 | 0 | 7.27 | .366 | 1.73 | 14.6 | 2.3 | 11.3 | 8.2 | 13 | 8 | 7 | 2 | 2 | 10 | 0 | 3 | 2 | 0 | 0 | 0 | 0 | 4.50 |