| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 85 | 34 | 34 | 13 | 14 | 3.73 | .301 | 1.26 | 7.8 | 3.6 | 8.5 | 214.2 | 185 | 98 | 89 | 22 | 86 | 202 | 2 | 0 | 0 | 1 | 23 | 6 | 8 | 3.74 |
| SP | McNally, D.McNally, Dave # >> | 26 | 1968 | L | 96 | 33 | 33 | 17 | 8 | 3.42 | .292 | 1.21 | 8.3 | 2.5 | 5.2 | 237.0 | 219 | 93 | 90 | 22 | 67 | 136 | 7 | 0 | 0 | 3 | 22 | 7 | 1 | 4.00 |
| SP | Cueto, J.Cueto, Johnny # >> | 28 | 2014 | R | 75 | 32 | 32 | 8 | 15 | 4.96 | .321 | 1.38 | 9.4 | 3.0 | 6.6 | 196.0 | 204 | 111 | 108 | 19 | 66 | 143 | 2 | 0 | 0 | 1 | 12 | 8 | 3 | 3.93 |
| SP | Cicotte, E.Cicotte, Eddie # >> | 33 | 1917 | R | 73 | 31 | 31 | 10 | 13 | 5.62 | .336 | 1.50 | 9.9 | 3.6 | 4.4 | 157.0 | 172 | 104 | 98 | 18 | 63 | 77 | 0 | 0 | 0 | 0 | 14 | 3 | 4 | 4.77 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 31 | 29 | 14 | 8 | 3.74 | .296 | 1.22 | 7.7 | 3.3 | 6.2 | 166.0 | 142 | 73 | 69 | 17 | 61 | 115 | 0 | 0 | 0 | 0 | 13 | 6 | 3 | 4.16 |
| RP | Miller, A.Miller, Andrew # >> | 29 | 2014 | L | 88 | 83 | 0 | 4 | 5 | 5.44 | .345 | 1.52 | 9.9 | 3.8 | 10.0 | 89.1 | 98 | 55 | 54 | 13 | 38 | 99 | 0 | 3 | 3 | 0 | 0 | 5 | 4 | 4.12 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 81 | 69 | 0 | 1 | 5 | 2.52 | .280 | 1.14 | 7.6 | 2.7 | 8.7 | 89.1 | 75 | 28 | 25 | 3 | 27 | 86 | 0 | 3 | 0 | 0 | 0 | 2 | 0 | 2.48 |
| RP | Hoffman, T.Hoffman, Trevor # >> | 31 | 1998 | R | 75 | 63 | 0 | 3 | 6 | 5.20 | .362 | 1.69 | 10.3 | 4.9 | 8.9 | 64.0 | 73 | 39 | 37 | 10 | 35 | 63 | 0 | 1 | 2 | 0 | 0 | 1 | 0 | 4.75 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 68 | 45 | 0 | 1 | 4 | 5.27 | .347 | 1.56 | 9.3 | 4.8 | 6.6 | 56.1 | 58 | 35 | 33 | 9 | 30 | 41 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 5.34 |
| SU | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 62 | 0 | 1 | 1 | 2.90 | .231 | 0.90 | 6.4 | 1.8 | 8.3 | 77.2 | 55 | 25 | 25 | 12 | 15 | 71 | 0 | 4 | 3 | 0 | 0 | 0 | 1 | 3.77 |
| CL | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 61 | 0 | 2 | 3 | 4.28 | .322 | 1.39 | 8.9 | 3.7 | 8.7 | 61.0 | 60 | 31 | 29 | 7 | 25 | 59 | 0 | 31 | 7 | 0 | 0 | 2 | 3 | 3.89 |