| SP | Skubal, T.Skubal, Tarik † # >> | 28 | 2025 | L | 100 | 33 | 33 | 19 | 8 | 2.52 | .270 | 1.07 | 7.6 | 2.0 | 10.7 | 229.0 | 194 | 66 | 64 | 18 | 51 | 273 | 2 | 0 | 0 | 1 | 25 | 9 | 4 | 2.42 |
| SP | Peralta, F.Peralta, Freddy † >> | 29 | 2025 | R | 89 | 32 | 32 | 18 | 8 | 3.00 | .302 | 1.29 | 7.4 | 4.3 | 10.0 | 180.0 | 147 | 61 | 60 | 20 | 85 | 199 | 0 | 0 | 0 | 0 | 11 | 2 | 7 | 3.68 |
| SP | Glasnow, T.Glasnow, Tyler >> | 31 | 2025 | R | 88 | 31 | 31 | 9 | 9 | 4.25 | .327 | 1.42 | 8.8 | 4.1 | 9.7 | 158.2 | 154 | 76 | 75 | 23 | 72 | 170 | 0 | 0 | 0 | 0 | 3 | 5 | 6 | 4.20 |
| SP | Horton, C.Horton, Cade >> | 23 | 2025 | R | 79 | 31 | 31 | 11 | 11 | 4.75 | .327 | 1.43 | 9.6 | 3.3 | 7.4 | 155.1 | 165 | 83 | 82 | 22 | 57 | 127 | 0 | 0 | 0 | 0 | 9 | 4 | 2 | 4.39 |
| SP | Williams, G.Williams, Gavin >> | 25 | 2025 | R | 70 | 30 | 30 | 6 | 12 | 6.84 | .373 | 1.77 | 10.5 | 5.5 | 9.9 | 146.0 | 170 | 111 | 111 | 28 | 89 | 161 | 0 | 0 | 0 | 0 | 7 | 2 | 8 | 5.16 |
| RP | Miller, M.Miller, Mason >> | 26 | 2025 | R | 98 | 78 | 0 | 3 | 3 | 3.22 | .256 | 1.03 | 5.2 | 4.1 | 11.2 | 111.2 | 64 | 40 | 40 | 11 | 51 | 138 | 0 | 0 | 2 | 0 | 0 | 0 | 3 | 3.18 |
| RP | Santana, D.Santana, Dennis >> | 29 | 2025 | R | 92 | 76 | 0 | 6 | 5 | 3.05 | .300 | 1.26 | 8.2 | 3.2 | 8.1 | 106.1 | 96 | 37 | 36 | 11 | 38 | 95 | 0 | 6 | 4 | 0 | 0 | 3 | 0 | 3.72 |
| RP | Munoz, A.Munoz, Andres >> | 26 | 2025 | R | 90 | 76 | 0 | 4 | 4 | 3.90 | .320 | 1.40 | 7.6 | 5.2 | 11.3 | 87.2 | 73 | 38 | 38 | 7 | 50 | 109 | 0 | 12 | 0 | 0 | 0 | 1 | 3 | 3.30 |
| RP | Strahm, M.Strahm, Matt >> | 33 | 2025 | L | 73 | 60 | 0 | 4 | 7 | 3.33 | .309 | 1.32 | 8.6 | 3.2 | 9.2 | 73.0 | 70 | 30 | 27 | 7 | 26 | 75 | 0 | 8 | 4 | 0 | 0 | 2 | 5 | 3.34 |
| RP | Sousa, B.Sousa, Bennett >> | 30 | 2025 | L | 81 | 46 | 0 | 3 | 3 | 4.44 | .293 | 1.24 | 7.2 | 4.1 | 10.1 | 50.2 | 40 | 25 | 25 | 5 | 23 | 56 | 0 | 9 | 1 | 0 | 0 | 0 | 1 | 3.44 |
| SP | Lodolo, N.Lodolo, Nick >> | 27 | 2025 | L | 78 | 9 | 0 | 0 | 0 | 4.91 | .305 | 1.24 | 9.5 | 1.8 | 8.8 | 40.1 | 42 | 22 | 22 | 7 | 8 | 39 | 0 | 1 | 0 | 0 | 0 | 3 | 1 | 4.15 |
| RP | Santillan, T.Santillan, Tony >> | 28 | 2025 | R | 72 | 26 | 0 | 2 | 1 | 5.14 | .394 | 1.90 | 10.7 | 6.4 | 8.6 | 21.0 | 25 | 12 | 12 | 1 | 15 | 20 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 4.00 |