| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 15 | 15 | 1 | 2 | 3.78 | .312 | 1.31 | 8.9 | 3.0 | 9.3 | 97.2 | 96 | 44 | 41 | 13 | 32 | 100 | 0 | 0 | 0 | 0 | 8 | 5 | 1 | 3.82 |
| SP | Glasnow, T.Glasnow, Tyler >> | 31 | 2025 | R | 88 | 14 | 14 | 6 | 3 | 3.16 | .315 | 1.38 | 7.2 | 5.2 | 9.2 | 74.0 | 59 | 27 | 26 | 7 | 43 | 76 | 0 | 0 | 0 | 0 | 2 | 0 | 2 | 3.92 |
| SP | Nelson, R.Nelson, Ryne >> | 27 | 2025 | R | 81 | 14 | 14 | 6 | 4 | 4.50 | .309 | 1.30 | 9.5 | 2.2 | 7.8 | 70.0 | 74 | 35 | 35 | 12 | 17 | 61 | 0 | 0 | 0 | 0 | 3 | 3 | 2 | 4.34 |
| RP | Miller, M.Miller, Mason >> | 26 | 2025 | R | 98 | 39 | 0 | 5 | 3 | 2.90 | .329 | 1.45 | 5.3 | 7.9 | 13.0 | 49.2 | 29 | 16 | 16 | 6 | 43 | 71 | 0 | 0 | 2 | 0 | 0 | 1 | 5 | 4.39 |
| RP | Santana, D.Santana, Dennis >> | 29 | 2025 | R | 92 | 40 | 0 | 3 | 0 | 2.65 | .273 | 1.13 | 6.6 | 3.6 | 8.1 | 57.2 | 42 | 19 | 17 | 4 | 23 | 51 | 0 | 8 | 0 | 0 | 0 | 0 | 0 | 3.33 |
| RP | Saalfrank, A.Saalfrank, Andrew >> | 27 | 2025 | L | 83 | 36 | 0 | 2 | 6 | 4.25 | .349 | 1.58 | 8.6 | 5.8 | 7.3 | 42.1 | 40 | 24 | 20 | 5 | 27 | 34 | 0 | 4 | 4 | 0 | 0 | 1 | 3 | 4.93 |
| RP | Sterner, J.Sterner, Justin >> | 28 | 2025 | R | 78 | 38 | 0 | 4 | 3 | 3.00 | .312 | 1.33 | 8.1 | 3.9 | 11.8 | 39.0 | 35 | 16 | 13 | 5 | 17 | 51 | 0 | 2 | 3 | 0 | 0 | 1 | 1 | 3.44 |
| RP | Megill, T.Megill, Trevor >> | 31 | 2025 | R | 70 | 27 | 0 | 0 | 4 | 3.99 | .296 | 1.16 | 8.4 | 2.2 | 12.1 | 29.1 | 27 | 14 | 13 | 4 | 7 | 39 | 0 | 2 | 2 | 0 | 0 | 3 | 0 | 3.14 |