| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 91 | 27 | 27 | 15 | 7 | 2.79 | .285 | 1.18 | 6.8 | 3.8 | 5.2 | 183.2 | 139 | 70 | 57 | 11 | 77 | 105 | 2 | 0 | 0 | 2 | 19 | 4 | 6 | 3.96 |
| SP | Mathewson, C.Mathewson, Christy † >> | 28 | 1908 | R | 83 | 27 | 27 | 18 | 6 | 3.46 | .281 | 1.16 | 8.3 | 2.2 | 5.7 | 200.1 | 185 | 84 | 77 | 22 | 48 | 127 | 6 | 0 | 0 | 0 | 18 | 2 | 4 | 3.91 |
| RP | Kimbrel, C.Kimbrel, Craig >> | 24 | 2012 | R | 100 | 68 | 0 | 3 | 1 | 2.65 | .288 | 1.22 | 6.4 | 4.6 | 9.4 | 51.0 | 36 | 18 | 15 | 6 | 26 | 53 | 0 | 2 | 0 | 0 | 0 | 0 | 4 | 3.98 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 80 | 28 | 0 | 4 | 2 | 2.00 | .270 | 1.11 | 6.0 | 4.0 | 7.3 | 27.0 | 18 | 7 | 6 | 2 | 12 | 22 | 0 | 7 | 0 | 0 | 0 | 0 | 0 | 3.67 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 77 | 16 | 0 | 1 | 2 | 5.19 | .307 | 1.33 | 10.6 | 1.6 | 5.8 | 17.1 | 20 | 11 | 10 | 2 | 3 | 11 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 3.76 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 16 | 0 | 0 | 1 | 3.52 | .303 | 1.30 | 7.2 | 4.8 | 7.2 | 15.1 | 12 | 6 | 6 | 2 | 8 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4.73 |
| SP | Chance, D.Chance, Dean >> | 23 | 1964 | R | 53 | 21 | 0 | 3 | 2 | 3.61 | .318 | 1.37 | 8.0 | 4.4 | 5.5 | 72.1 | 64 | 33 | 29 | 6 | 35 | 44 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 4.40 |