| SP | Kershaw, C.Kershaw, Clayton † >> | 28 | 2016 | L | 99 | 31 | 31 | 17 | 5 | 3.14 | .279 | 1.15 | 8.1 | 2.3 | 8.2 | 212.1 | 191 | 74 | 74 | 30 | 54 | 194 | 7 | 0 | 0 | 0 | 23 | 2 | 2 | 3.80 |
| SP | Fernandez, S.Fernandez, Sid >> | 23 | 1985 | L | 49 | 28 | 28 | 13 | 5 | 4.23 | .302 | 1.30 | 7.4 | 4.4 | 7.5 | 180.2 | 147 | 88 | 85 | 21 | 87 | 149 | 2 | 0 | 0 | 1 | 11 | 1 | 6 | 4.33 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 81 | 0 | 8 | 2 | 3.50 | .256 | 1.03 | 5.8 | 3.5 | 8.9 | 82.1 | 53 | 32 | 32 | 6 | 32 | 81 | 0 | 5 | 4 | 0 | 0 | 0 | 0 | 3.15 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 80 | 0 | 5 | 2 | 3.15 | .297 | 1.27 | 6.3 | 5.1 | 8.0 | 60.0 | 42 | 26 | 21 | 3 | 34 | 53 | 0 | 4 | 3 | 0 | 0 | 0 | 0 | 3.58 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 84 | 59 | 0 | 4 | 2 | 2.80 | .305 | 1.28 | 6.8 | 4.8 | 8.5 | 54.2 | 41 | 20 | 17 | 3 | 29 | 51 | 0 | 8 | 4 | 0 | 0 | 2 | 0 | 3.56 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 36 | 0 | 3 | 5 | 3.82 | .324 | 1.43 | 6.9 | 6.3 | 9.3 | 30.2 | 23 | 15 | 13 | 4 | 21 | 31 | 0 | 5 | 3 | 0 | 0 | 0 | 3 | 4.77 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 69 | 30 | 0 | 3 | 1 | 3.16 | .277 | 1.15 | 7.0 | 3.5 | 8.1 | 31.1 | 24 | 11 | 11 | 4 | 12 | 28 | 0 | 1 | 2 | 0 | 0 | 0 | 2 | 4.03 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 15 | 3 | 3 | 0 | 2.84 | .294 | 1.22 | 7.6 | 3.5 | 5.1 | 69.2 | 58 | 27 | 22 | 1 | 27 | 39 | 1 | 1 | 0 | 0 | 1 | 2 | 5 | 3.32 |