| SP | deGrom, J.deGrom, Jacob $$ >> | 33 | 2021 | R | 100 | 29 | 29 | 14 | 8 | 3.48 | .272 | 1.10 | 7.7 | 2.3 | 9.5 | 196.2 | 168 | 76 | 76 | 29 | 49 | 207 | 1 | 0 | 0 | 0 | 19 | 3 | 0 | 3.61 |
| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 28 | 28 | 8 | 11 | 4.78 | .310 | 1.34 | 8.3 | 3.8 | 8.8 | 175.0 | 162 | 93 | 93 | 20 | 73 | 171 | 3 | 0 | 0 | 1 | 13 | 1 | 2 | 3.80 |
| SP | Cole, G.Cole, Gerrit # >> | 28 | 2019 | R | 92 | 28 | 28 | 10 | 10 | 4.47 | .319 | 1.37 | 9.1 | 3.3 | 8.3 | 179.0 | 180 | 90 | 89 | 27 | 66 | 165 | 4 | 0 | 0 | 1 | 13 | 5 | 1 | 4.31 |
| SP | Cueto, J.Cueto, Johnny # >> | 28 | 2014 | R | 75 | 26 | 26 | 16 | 6 | 4.11 | .287 | 1.20 | 7.9 | 3.0 | 8.2 | 190.1 | 166 | 88 | 87 | 25 | 63 | 174 | 4 | 0 | 0 | 2 | 14 | 1 | 2 | 3.89 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 98 | 79 | 0 | 2 | 6 | 2.88 | .246 | 0.95 | 5.8 | 2.8 | 8.8 | 112.2 | 72 | 36 | 36 | 15 | 35 | 109 | 0 | 9 | 5 | 0 | 0 | 3 | 2 | 3.81 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 64 | 0 | 3 | 8 | 4.28 | .288 | 1.19 | 6.5 | 4.3 | 8.2 | 75.2 | 54 | 36 | 36 | 7 | 36 | 68 | 0 | 8 | 2 | 0 | 0 | 2 | 0 | 3.92 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 92 | 43 | 0 | 3 | 3 | 4.08 | .293 | 1.25 | 7.6 | 3.6 | 7.0 | 53.0 | 45 | 24 | 24 | 5 | 21 | 41 | 0 | 7 | 2 | 0 | 0 | 0 | 0 | 3.87 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 22 | 0 | 3 | 0 | 1.75 | .222 | 0.86 | 5.8 | 2.2 | 7.6 | 25.2 | 16 | 5 | 5 | 2 | 6 | 21 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 3.08 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 82 | 23 | 0 | 1 | 1 | 6.04 | .309 | 1.30 | 7.9 | 4.0 | 4.7 | 25.1 | 22 | 17 | 17 | 8 | 11 | 13 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 7.56 |