| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 15 | 15 | 6 | 4 | 3.49 | .297 | 1.22 | 7.8 | 3.3 | 9.2 | 116.0 | 100 | 47 | 45 | 16 | 42 | 118 | 4 | 0 | 0 | 0 | 10 | 5 | 5 | 3.97 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 90 | 15 | 15 | 3 | 7 | 5.71 | .321 | 1.42 | 9.5 | 3.3 | 9.4 | 99.1 | 105 | 63 | 63 | 17 | 36 | 103 | 4 | 0 | 0 | 1 | 5 | 0 | 1 | 4.24 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 67 | 14 | 14 | 5 | 4 | 5.76 | .335 | 1.49 | 10.6 | 2.9 | 7.0 | 90.2 | 106 | 59 | 58 | 13 | 29 | 70 | 2 | 0 | 0 | 1 | 4 | 2 | 2 | 4.36 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 43 | 0 | 3 | 3 | 2.12 | .209 | 0.78 | 5.2 | 1.8 | 8.4 | 59.1 | 34 | 14 | 14 | 6 | 12 | 55 | 0 | 4 | 1 | 0 | 0 | 1 | 0 | 3.12 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 38 | 0 | 4 | 5 | 4.89 | .298 | 1.28 | 8.6 | 3.0 | 8.4 | 42.1 | 40 | 23 | 23 | 9 | 14 | 39 | 0 | 3 | 3 | 0 | 0 | 0 | 0 | 4.93 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 79 | 21 | 0 | 2 | 1 | 4.98 | .323 | 1.43 | 8.1 | 5.1 | 6.9 | 21.2 | 19 | 12 | 12 | 2 | 12 | 16 | 0 | 4 | 0 | 0 | 0 | 0 | 1 | 4.43 |