| SP | Greinke, Z.Greinke, Zack >> | 32 | 2015 | R | 94 | 28 | 28 | 7 | 13 | 5.02 | .321 | 1.35 | 8.7 | 3.5 | 5.7 | 166.2 | 160 | 95 | 93 | 23 | 65 | 105 | 5 | 0 | 0 | 0 | 13 | 11 | 1 | 4.91 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 28 | 28 | 4 | 15 | 6.66 | .347 | 1.55 | 11.2 | 2.8 | 6.6 | 143.1 | 178 | 117 | 106 | 37 | 44 | 105 | 0 | 0 | 0 | 0 | 8 | 6 | 11 | 5.94 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 85 | 27 | 27 | 6 | 11 | 4.74 | .316 | 1.37 | 9.2 | 3.1 | 4.5 | 133.0 | 136 | 75 | 70 | 14 | 46 | 66 | 0 | 0 | 0 | 0 | 8 | 2 | 2 | 4.46 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 85 | 27 | 27 | 13 | 9 | 3.83 | .305 | 1.29 | 9.0 | 2.7 | 4.0 | 164.2 | 164 | 76 | 70 | 22 | 49 | 73 | 3 | 0 | 0 | 2 | 16 | 4 | 2 | 4.82 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 25 | 25 | 4 | 12 | 5.29 | .342 | 1.55 | 10.2 | 3.8 | 7.7 | 136.0 | 154 | 90 | 80 | 24 | 57 | 116 | 1 | 0 | 0 | 0 | 7 | 1 | 2 | 4.87 |
| CL | Wagner, B.Wagner, Billy † >> | 28 | 1999 | L | 95 | 52 | 0 | 1 | 1 | 2.63 | .284 | 1.19 | 6.0 | 4.8 | 8.8 | 51.1 | 34 | 17 | 15 | 3 | 27 | 50 | 0 | 28 | 1 | 0 | 0 | 0 | 1 | 3.39 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 63 | 0 | 5 | 3 | 5.30 | .348 | 1.60 | 7.6 | 6.8 | 10.7 | 73.0 | 62 | 45 | 43 | 8 | 55 | 87 | 0 | 0 | 4 | 0 | 0 | 0 | 4 | 4.30 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 76 | 65 | 0 | 7 | 3 | 3.89 | .331 | 1.47 | 8.1 | 5.1 | 7.9 | 74.0 | 67 | 40 | 32 | 6 | 42 | 65 | 0 | 1 | 1 | 0 | 0 | 1 | 7 | 4.04 |
| RP | Wilhelm, H.Wilhelm, Hoyt >> | 43 | 1965 | R | 69 | 56 | 0 | 4 | 7 | 5.97 | .305 | 1.32 | 9.2 | 2.6 | 5.7 | 92.0 | 94 | 62 | 61 | 16 | 27 | 58 | 0 | 1 | 0 | 0 | 0 | 0 | 7 | 4.88 |
| SP | Bender, C.Bender, Chief >> | 26 | 1910 | R | 72 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 69 | 18 | 0 | 3 | 0 | 4.27 | .302 | 1.29 | 8.2 | 3.5 | 7.2 | 92.2 | 84 | 48 | 44 | 21 | 36 | 74 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 5.53 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 11 | 0 | 3 | 0 | 2.89 | .333 | 1.50 | 10.0 | 4.0 | 7.0 | 9.1 | 10 | 3 | 3 | 2 | 4 | 7 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 5.67 |