| SP | Kershaw, C.Kershaw, Clayton >> | 28 | 2016 | L | 99 | 15 | 15 | 1 | 11 | 7.98 | .341 | 1.50 | 11.8 | 1.7 | 8.1 | 73.1 | 96 | 67 | 65 | 18 | 14 | 66 | 0 | 0 | 0 | 0 | 2 | 4 | 3 | 5.14 |
| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 91 | 15 | 15 | 5 | 5 | 4.21 | .315 | 1.35 | 7.4 | 4.7 | 5.7 | 92.0 | 76 | 43 | 43 | 12 | 48 | 58 | 0 | 0 | 0 | 0 | 6 | 3 | 1 | 5.10 |
| SP | Hernandez, F.Hernandez, Felix # >> | 28 | 2014 | R | 80 | 15 | 15 | 2 | 6 | 6.29 | .340 | 1.53 | 11.5 | 2.4 | 9.5 | 68.2 | 87 | 53 | 48 | 14 | 18 | 72 | 0 | 0 | 0 | 0 | 4 | 1 | 3 | 4.40 |
| SP | Cueto, J.Cueto, Johnny >> | 28 | 2014 | R | 75 | 15 | 15 | 8 | 4 | 3.60 | .317 | 1.33 | 8.6 | 3.3 | 6.2 | 100.0 | 96 | 41 | 40 | 4 | 37 | 69 | 3 | 0 | 0 | 1 | 10 | 6 | 1 | 3.43 |
| CL | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 37 | 0 | 4 | 7 | 7.21 | .358 | 1.65 | 9.0 | 6.1 | 8.6 | 43.2 | 43 | 38 | 35 | 8 | 29 | 41 | 0 | 8 | 5 | 0 | 0 | 1 | 0 | 5.60 |
| SU | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 91 | 39 | 0 | 1 | 2 | 4.43 | .318 | 1.38 | 9.5 | 3.2 | 7.4 | 40.2 | 42 | 22 | 20 | 9 | 14 | 33 | 0 | 2 | 4 | 0 | 0 | 1 | 0 | 5.40 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 80 | 46 | 0 | 4 | 1 | 5.72 | .351 | 1.58 | 9.8 | 4.6 | 9.4 | 45.2 | 49 | 32 | 29 | 8 | 23 | 47 | 0 | 2 | 0 | 0 | 0 | 2 | 0 | 4.89 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 40 | 0 | 2 | 1 | 4.44 | .298 | 1.23 | 9.3 | 1.9 | 6.8 | 52.2 | 54 | 27 | 26 | 5 | 11 | 39 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 3.50 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 39 | 0 | 0 | 1 | 5.01 | .340 | 1.52 | 8.6 | 5.3 | 8.6 | 41.1 | 39 | 30 | 23 | 9 | 24 | 39 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 5.78 |