| SP | Guidry, R.Guidry, Ron # >> | 28 | 1978 | L | 78 | 33 | 33 | 18 | 11 | 3.64 | .299 | 1.25 | 8.7 | 2.6 | 4.6 | 235.0 | 226 | 101 | 95 | 21 | 68 | 121 | 6 | 0 | 0 | 2 | 21 | 6 | 9 | 4.08 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 90 | 34 | 33 | 16 | 15 | 3.74 | .306 | 1.30 | 8.7 | 3.0 | 7.5 | 243.1 | 234 | 109 | 101 | 30 | 82 | 202 | 10 | 1 | 0 | 2 | 17 | 6 | 6 | 4.03 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 33 | 32 | 9 | 14 | 5.62 | .333 | 1.47 | 11.1 | 2.2 | 8.4 | 198.2 | 244 | 132 | 124 | 26 | 48 | 185 | 0 | 0 | 0 | 0 | 13 | 5 | 1 | 3.64 |
| SP | Camnitz, H.Camnitz, Howie >> | 28 | 1909 | R | 58 | 14 | 5 | 1 | 4 | 5.90 | .333 | 1.47 | 9.8 | 3.4 | 4.7 | 58.0 | 63 | 38 | 38 | 8 | 22 | 30 | 0 | 1 | 0 | 0 | 2 | 2 | 2 | 5.00 |
| SP | Alexander, P.Alexander, Pete >> | 28 | 1915 | R | 88 | 33 | 33 | 7 | 18 | 5.46 | .321 | 1.41 | 10.1 | 2.6 | 4.5 | 226.0 | 253 | 141 | 137 | 26 | 65 | 112 | 4 | 0 | 0 | 0 | 10 | 3 | 4 | 4.41 |
| CL | Nathan, J.Nathan, Joe † >> | 32 | 2006 | R | 86 | 68 | 0 | 7 | 5 | 2.64 | .248 | 0.96 | 5.7 | 3.0 | 8.9 | 71.2 | 45 | 21 | 21 | 8 | 24 | 70 | 0 | 28 | 7 | 0 | 0 | 2 | 2 | 3.59 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 59 | 0 | 3 | 1 | 2.71 | .304 | 1.28 | 7.0 | 4.6 | 9.1 | 66.1 | 51 | 20 | 20 | 6 | 34 | 67 | 0 | 0 | 0 | 0 | 0 | 2 | 3 | 3.79 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 74 | 0 | 5 | 1 | 3.36 | .292 | 1.23 | 7.4 | 3.7 | 5.1 | 85.2 | 70 | 33 | 32 | 10 | 35 | 48 | 0 | 4 | 1 | 0 | 0 | 1 | 6 | 4.67 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 43 | 0 | 3 | 0 | 4.29 | .329 | 1.45 | 9.0 | 4.1 | 9.9 | 50.1 | 50 | 24 | 24 | 9 | 23 | 55 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 4.58 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 84 | 44 | 0 | 5 | 3 | 4.44 | .333 | 1.50 | 8.6 | 5.1 | 6.7 | 46.2 | 44 | 24 | 23 | 6 | 26 | 34 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 4.91 |
| SP | Cicotte, E.Cicotte, Eddie # >> | 33 | 1917 | R | 74 | 29 | 26 | 6 | 10 | 5.58 | .340 | 1.50 | 9.6 | 3.9 | 4.7 | 172.2 | 184 | 117 | 107 | 23 | 75 | 89 | 2 | 0 | 0 | 0 | 11 | 8 | 2 | 5.15 |