| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 36 | 36 | 17 | 11 | 3.20 | .270 | 1.10 | 7.4 | 2.5 | 10.0 | 236.1 | 193 | 95 | 84 | 25 | 66 | 261 | 1 | 0 | 0 | 1 | 24 | 3 | 0 | 3.04 |
| SP | Cole, G.Cole, Gerrit # >> | 28 | 2019 | R | 92 | 33 | 33 | 6 | 14 | 5.46 | .328 | 1.43 | 10.2 | 2.7 | 8.5 | 196.1 | 222 | 128 | 119 | 34 | 58 | 185 | 1 | 0 | 0 | 0 | 14 | 7 | 2 | 4.36 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 31 | 31 | 8 | 16 | 5.36 | .335 | 1.51 | 10.5 | 3.2 | 4.4 | 196.1 | 228 | 127 | 117 | 25 | 69 | 96 | 4 | 0 | 0 | 0 | 14 | 0 | 5 | 4.73 |
| RP | Doolittle, S.Doolittle, Sean † >> | 31 | 2018 | L | 99 | 91 | 0 | 11 | 5 | 3.27 | .243 | 0.96 | 6.4 | 2.3 | 9.4 | 126.2 | 90 | 46 | 46 | 12 | 32 | 131 | 0 | 13 | 1 | 0 | 0 | 0 | 0 | 2.92 |
| RP | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 97 | 61 | 0 | 9 | 1 | 2.99 | .307 | 1.30 | 8.4 | 3.4 | 8.8 | 72.1 | 67 | 30 | 24 | 7 | 27 | 70 | 0 | 4 | 4 | 0 | 0 | 2 | 0 | 3.53 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 31 | 0 | 0 | 3 | 4.37 | .335 | 1.51 | 8.7 | 4.9 | 9.3 | 35.0 | 34 | 18 | 17 | 5 | 19 | 36 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4.43 |
| RP | Foulke, K.Foulke, Keith # >> | 27 | 1999 | R | 60 | 44 | 0 | 2 | 2 | 6.59 | .339 | 1.54 | 11.4 | 2.6 | 8.4 | 42.1 | 53 | 32 | 31 | 14 | 12 | 39 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 6.33 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 59 | 15 | 0 | 2 | 1 | 1.46 | .282 | 1.18 | 7.5 | 3.4 | 3.0 | 24.2 | 20 | 5 | 4 | 0 | 9 | 8 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 3.46 |