| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 18 | 18 | 8 | 3 | 2.91 | .257 | 1.04 | 6.9 | 2.5 | 9.6 | 120.2 | 92 | 39 | 39 | 11 | 33 | 128 | 0 | 0 | 0 | 0 | 13 | 0 | 0 | 2.88 |
| SP | Johnson, W.Johnson, Walter >> | 26 | 1913 | R | 95 | 18 | 18 | 7 | 7 | 3.77 | .277 | 1.13 | 8.1 | 2.2 | 3.0 | 121.2 | 109 | 52 | 51 | 11 | 29 | 40 | 5 | 0 | 0 | 2 | 9 | 2 | 2 | 4.29 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 85 | 17 | 17 | 10 | 4 | 4.36 | .297 | 1.22 | 8.2 | 2.8 | 4.0 | 126.0 | 115 | 63 | 61 | 13 | 39 | 56 | 4 | 0 | 0 | 0 | 9 | 6 | 4 | 4.52 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 17 | 17 | 3 | 8 | 5.96 | .370 | 1.75 | 11.4 | 4.5 | 8.0 | 102.2 | 129 | 72 | 68 | 19 | 51 | 91 | 1 | 0 | 0 | 0 | 5 | 1 | 1 | 5.17 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 55 | 0 | 4 | 4 | 4.30 | .340 | 1.50 | 8.8 | 4.7 | 8.0 | 44.0 | 43 | 25 | 21 | 3 | 23 | 39 | 0 | 3 | 3 | 0 | 0 | 2 | 0 | 3.82 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 59 | 0 | 1 | 5 | 4.84 | .361 | 1.70 | 9.8 | 5.7 | 9.5 | 35.1 | 38 | 20 | 19 | 7 | 22 | 37 | 0 | 5 | 4 | 0 | 0 | 0 | 2 | 5.37 |
| RP | Sutter, B.Sutter, Bruce >> | 24 | 1977 | R | 69 | 40 | 0 | 3 | 0 | 3.66 | .338 | 1.50 | 9.0 | 4.5 | 8.4 | 32.0 | 32 | 13 | 13 | 4 | 16 | 30 | 0 | 2 | 4 | 0 | 0 | 1 | 4 | 4.34 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 68 | 29 | 0 | 1 | 0 | 3.38 | .252 | 1.01 | 6.9 | 2.4 | 8.0 | 26.2 | 20 | 10 | 10 | 4 | 7 | 23 | 0 | 8 | 0 | 0 | 0 | 0 | 0 | 4.04 |
| RP | Niedenfuer, T.Niedenfuer, Tom >> | 24 | 1983 | R | 62 | 16 | 0 | 5 | 1 | 4.00 | .357 | 1.67 | 10.5 | 4.5 | 7.5 | 18.0 | 21 | 8 | 8 | 4 | 9 | 15 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.72 |