| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 16 | 16 | 4 | 7 | 4.77 | .302 | 1.29 | 8.6 | 3.1 | 6.7 | 105.2 | 100 | 59 | 56 | 13 | 36 | 78 | 1 | 0 | 0 | 0 | 8 | 1 | 3 | 4.18 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 90 | 16 | 16 | 4 | 7 | 4.34 | .335 | 1.48 | 9.1 | 4.3 | 7.6 | 95.1 | 96 | 47 | 46 | 13 | 45 | 80 | 3 | 0 | 0 | 0 | 8 | 3 | 0 | 4.61 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 83 | 16 | 16 | 2 | 5 | 5.70 | .354 | 1.64 | 10.9 | 3.9 | 8.2 | 90.0 | 109 | 60 | 57 | 10 | 39 | 82 | 0 | 0 | 0 | 0 | 6 | 0 | 3 | 3.92 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 15 | 15 | 3 | 8 | 6.99 | .352 | 1.63 | 9.0 | 5.7 | 9.0 | 76.0 | 76 | 59 | 59 | 13 | 48 | 76 | 0 | 0 | 0 | 0 | 4 | 0 | 3 | 5.12 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 16 | 15 | 5 | 8 | 5.53 | .317 | 1.39 | 10.2 | 2.3 | 4.3 | 81.1 | 92 | 52 | 50 | 10 | 21 | 39 | 1 | 0 | 0 | 1 | 5 | 0 | 4 | 4.42 |
| SU | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 97 | 51 | 0 | 0 | 3 | 5.21 | .327 | 1.44 | 10.1 | 2.8 | 8.7 | 57.0 | 64 | 34 | 33 | 10 | 18 | 55 | 0 | 1 | 3 | 0 | 0 | 1 | 1 | 4.35 |
| CL | Gossage, R.Gossage, Rich >> | 30 | 1981 | R | 89 | 43 | 0 | 2 | 4 | 3.34 | .300 | 1.27 | 7.6 | 4.0 | 9.3 | 56.2 | 47 | 23 | 21 | 10 | 25 | 58 | 0 | 12 | 4 | 0 | 0 | 1 | 0 | 4.64 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 83 | 47 | 0 | 6 | 5 | 6.63 | .351 | 1.60 | 8.5 | 6.0 | 7.7 | 54.1 | 51 | 42 | 40 | 11 | 36 | 46 | 0 | 1 | 3 | 0 | 0 | 1 | 2 | 6.00 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 43 | 0 | 1 | 1 | 3.70 | .324 | 1.42 | 6.2 | 6.8 | 9.0 | 48.2 | 33 | 21 | 20 | 1 | 36 | 48 | 0 | 1 | 0 | 0 | 0 | 1 | 2 | 3.58 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 31 | 0 | 1 | 2 | 5.70 | .326 | 1.45 | 9.4 | 3.9 | 7.5 | 42.2 | 44 | 27 | 27 | 8 | 18 | 35 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 5.10 |