| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 6 | 6 | 2 | 0 | 1.99 | .261 | 1.06 | 7.0 | 2.7 | 9.2 | 40.2 | 31 | 9 | 9 | 4 | 12 | 41 | 0 | 0 | 0 | 0 | 5 | 0 | 0 | 3.15 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 90 | 6 | 6 | 1 | 2 | 7.28 | .369 | 1.72 | 11.8 | 4.0 | 8.7 | 29.2 | 38 | 25 | 24 | 3 | 13 | 28 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 3.86 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 74 | 5 | 5 | 1 | 3 | 4.70 | .276 | 1.11 | 8.1 | 2.1 | 7.2 | 30.2 | 27 | 16 | 16 | 4 | 7 | 24 | 2 | 0 | 0 | 0 | 3 | 1 | 0 | 3.93 |
| SU | Chapman, A.Chapman, Aroldis >> | 26 | 2014 | L | 94 | 13 | 0 | 1 | 0 | 5.40 | .274 | 1.13 | 7.2 | 3.0 | 9.0 | 15.0 | 12 | 9 | 9 | 1 | 5 | 15 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 2.87 |
| CL | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 13 | 0 | 0 | 1 | 3.71 | .261 | 1.06 | 7.4 | 2.1 | 7.4 | 17.0 | 14 | 7 | 7 | 1 | 4 | 14 | 0 | 4 | 1 | 0 | 0 | 0 | 0 | 2.82 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 82 | 11 | 0 | 2 | 0 | 4.20 | .338 | 1.33 | 6.0 | 6.0 | 3.0 | 15.0 | 10 | 7 | 7 | 0 | 10 | 5 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 4.93 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 13 | 0 | 1 | 1 | 5.40 | .286 | 1.20 | 8.4 | 2.4 | 9.0 | 15.0 | 14 | 9 | 9 | 5 | 4 | 15 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 6.13 |
| RP | Sutter, B.Sutter, Bruce >> | 24 | 1977 | R | 68 | 10 | 0 | 1 | 0 | 10.22 | .362 | 1.70 | 12.8 | 3.0 | 6.8 | 12.1 | 17 | 14 | 14 | 3 | 4 | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 5.75 |