| SP | Schmidt, J.Schmidt, Jason # >> | 30 | 2003 | R | 78 | 23 | 23 | 4 | 13 | 5.30 | .345 | 1.55 | 11.4 | 2.7 | 9.0 | 149.1 | 188 | 94 | 88 | 28 | 44 | 149 | 1 | 0 | 0 | 1 | 9 | 4 | 8 | 4.41 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 75 | 23 | 23 | 1 | 7 | 4.49 | .334 | 1.46 | 9.4 | 3.8 | 9.7 | 100.1 | 104 | 50 | 50 | 12 | 42 | 108 | 0 | 0 | 0 | 0 | 1 | 5 | 4 | 3.81 |
| SP | Valenzuela, F.Valenzuela, Fernando # >> | 21 | 1981 | L | 61 | 22 | 22 | 7 | 10 | 6.60 | .375 | 1.77 | 10.3 | 5.6 | 8.0 | 131.0 | 150 | 96 | 96 | 25 | 82 | 117 | 0 | 0 | 0 | 0 | 7 | 4 | 7 | 5.66 |
| RP | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 96 | 61 | 0 | 5 | 2 | 2.51 | .263 | 1.06 | 6.0 | 3.6 | 9.7 | 86.0 | 57 | 25 | 24 | 8 | 34 | 93 | 0 | 6 | 3 | 0 | 0 | 1 | 1 | 3.27 |
| RP | Rodney, F.Rodney, Fernando >> | 35 | 2012 | R | 80 | 56 | 0 | 5 | 3 | 5.10 | .343 | 1.52 | 10.9 | 2.8 | 8.5 | 67.0 | 81 | 40 | 38 | 8 | 21 | 63 | 0 | 5 | 3 | 0 | 0 | 3 | 2 | 3.75 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 62 | 49 | 0 | 5 | 6 | 4.50 | .331 | 1.42 | 7.3 | 5.5 | 9.1 | 62.0 | 50 | 31 | 31 | 7 | 38 | 63 | 0 | 3 | 3 | 0 | 0 | 4 | 2 | 4.47 |
| RP | Urbina, U.Urbina, Ugueth >> | 24 | 1998 | R | 56 | 41 | 0 | 2 | 3 | 6.11 | .301 | 1.29 | 7.6 | 4.2 | 9.8 | 45.2 | 38 | 32 | 31 | 8 | 21 | 49 | 0 | 3 | 3 | 0 | 0 | 0 | 1 | 4.53 |
| SP | Wainwright, A.Wainwright, Adam >> | 29 | 2010 | R | 47 | 6 | 0 | 0 | 0 | 5.40 | .375 | 1.70 | 11.7 | 3.6 | 4.5 | 10.0 | 13 | 6 | 6 | 1 | 4 | 5 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.80 |
| SP | Weaver, J.Weaver, Jered >> | 29 | 2011 | R | 54 | 40 | 0 | 3 | 5 | 3.95 | .303 | 1.29 | 8.5 | 3.2 | 6.8 | 68.1 | 64 | 33 | 30 | 15 | 24 | 51 | 0 | 4 | 3 | 0 | 0 | 1 | 3 | 5.47 |