| SP | Santana, J.Santana, Johan † >> | 25 | 2004 | L | 91 | 23 | 23 | 11 | 6 | 4.15 | .290 | 1.21 | 7.6 | 3.4 | 9.0 | 160.2 | 135 | 79 | 74 | 23 | 60 | 160 | 3 | 0 | 0 | 1 | 13 | 2 | 2 | 4.03 |
| SP | Clemens, R.Clemens, Roger # >> | 24 | 1986 | R | 79 | 23 | 23 | 9 | 9 | 4.98 | .308 | 1.32 | 8.9 | 3.1 | 7.9 | 162.2 | 160 | 92 | 90 | 27 | 55 | 142 | 6 | 0 | 0 | 0 | 11 | 2 | 3 | 4.47 |
| SP | Tanana, F.Tanana, Frank >> | 23 | 1976 | L | 74 | 23 | 23 | 8 | 6 | 5.21 | .318 | 1.38 | 8.7 | 3.8 | 6.4 | 141.2 | 136 | 83 | 82 | 21 | 60 | 101 | 2 | 0 | 0 | 0 | 13 | 2 | 3 | 4.82 |
| SP | Saberhagen, B.Saberhagen, Bret † >> | 25 | 1989 | R | 66 | 22 | 22 | 11 | 6 | 4.94 | .303 | 1.28 | 8.9 | 2.6 | 4.9 | 140.1 | 138 | 80 | 77 | 22 | 41 | 76 | 2 | 0 | 0 | 0 | 11 | 4 | 1 | 4.92 |
| RP | Benoit, J.Benoit, Joaquin >> | 33 | 2010 | R | 94 | 43 | 0 | 4 | 1 | 3.41 | .230 | 0.90 | 5.6 | 2.5 | 10.9 | 58.0 | 36 | 22 | 22 | 7 | 16 | 70 | 0 | 3 | 2 | 0 | 0 | 0 | 0 | 2.98 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 23 | 0 | 2 | 4 | 6.46 | .366 | 1.65 | 11.3 | 3.9 | 14.5 | 23.2 | 29 | 17 | 17 | 6 | 10 | 37 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 4.74 |
| CL | Uehara, K.Uehara, Koji # >> | 38 | 2013 | R | 100 | 50 | 0 | 2 | 5 | 4.35 | .291 | 1.23 | 8.9 | 2.3 | 10.8 | 72.1 | 71 | 36 | 35 | 9 | 18 | 86 | 0 | 13 | 6 | 0 | 0 | 0 | 0 | 2.99 |