| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 91 | 9 | 9 | 6 | 2 | 4.24 | .301 | 1.26 | 7.9 | 3.4 | 8.3 | 68.0 | 60 | 32 | 32 | 8 | 26 | 63 | 4 | 0 | 0 | 1 | 6 | 2 | 0 | 3.91 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 78 | 9 | 8 | 3 | 6 | 4.63 | .313 | 1.35 | 9.2 | 3.1 | 7.9 | 56.1 | 57 | 31 | 29 | 11 | 19 | 49 | 1 | 0 | 0 | 0 | 4 | 1 | 2 | 4.88 |
| SP | Saberhagen, B.Saberhagen, Bret >> | 25 | 1989 | R | 66 | 8 | 8 | 2 | 3 | 6.08 | .343 | 1.56 | 11.1 | 3.1 | 7.5 | 47.1 | 58 | 34 | 32 | 4 | 16 | 39 | 0 | 0 | 0 | 0 | 3 | 0 | 4 | 3.47 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 98 | 23 | 0 | 2 | 0 | 1.93 | .269 | 1.04 | 5.9 | 3.7 | 9.3 | 32.2 | 21 | 7 | 7 | 3 | 13 | 33 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 3.56 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 74 | 11 | 0 | 0 | 1 | 1.80 | .167 | 0.60 | 3.6 | 1.8 | 9.0 | 15.0 | 6 | 3 | 3 | 0 | 3 | 15 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.60 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 76 | 10 | 0 | 0 | 0 | 1.35 | .245 | 0.98 | 6.2 | 2.8 | 11.1 | 13.1 | 9 | 2 | 2 | 1 | 4 | 16 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 2.46 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 15 | 0 | 1 | 0 | 5.09 | .312 | 1.36 | 7.9 | 4.8 | 12.2 | 17.2 | 15 | 10 | 10 | 2 | 9 | 23 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.41 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 14 | 0 | 3 | 1 | 5.02 | .328 | 1.47 | 7.7 | 5.8 | 9.6 | 14.1 | 12 | 9 | 8 | 3 | 9 | 15 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 5.57 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 90 | 9 | 0 | 0 | 0 | 9.35 | .381 | 1.85 | 11.3 | 6.8 | 11.3 | 8.2 | 10 | 9 | 9 | 3 | 6 | 10 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 7.63 |