| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 32 | 32 | 15 | 6 | 3.51 | .263 | 1.04 | 7.1 | 2.2 | 9.0 | 218.0 | 173 | 88 | 85 | 23 | 53 | 217 | 0 | 0 | 0 | 0 | 20 | 7 | 0 | 3.21 |
| SP | Scott, M.Scott, Mike † # >> | 31 | 1986 | R | 87 | 31 | 31 | 16 | 9 | 3.72 | .282 | 1.15 | 7.9 | 2.5 | 7.9 | 220.0 | 194 | 107 | 91 | 17 | 60 | 194 | 5 | 0 | 0 | 4 | 17 | 5 | 4 | 3.13 |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 69 | 28 | 15 | 10 | 5 | 4.65 | .305 | 1.30 | 8.1 | 3.7 | 5.2 | 137.1 | 123 | 73 | 71 | 16 | 56 | 79 | 2 | 0 | 0 | 0 | 6 | 2 | 11 | 4.64 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 32 | 29 | 10 | 12 | 4.90 | .334 | 1.49 | 8.2 | 5.2 | 8.4 | 174.1 | 159 | 108 | 95 | 26 | 101 | 163 | 1 | 0 | 0 | 0 | 14 | 2 | 5 | 4.84 |
| CL | Adams, M.Adams, Mike † $ >> | 31 | 2009 | R | 99 | 65 | 0 | 1 | 7 | 2.63 | .267 | 1.09 | 6.8 | 3.0 | 7.5 | 65.0 | 49 | 23 | 19 | 6 | 22 | 54 | 0 | 45 | 4 | 0 | 0 | 0 | 0 | 3.55 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 77 | 47 | 0 | 1 | 4 | 3.11 | .266 | 1.09 | 6.6 | 3.4 | 8.8 | 37.2 | 27 | 13 | 13 | 2 | 14 | 36 | 0 | 1 | 3 | 0 | 0 | 0 | 0 | 2.89 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 45 | 0 | 2 | 4 | 3.89 | .307 | 1.30 | 10.3 | 1.6 | 10.3 | 34.2 | 39 | 18 | 15 | 3 | 6 | 39 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 2.47 |
| RP | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 88 | 74 | 0 | 5 | 3 | 3.66 | .320 | 1.41 | 8.4 | 4.5 | 9.4 | 46.2 | 43 | 20 | 19 | 6 | 23 | 48 | 0 | 1 | 3 | 0 | 0 | 0 | 3 | 4.11 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 75 | 12 | 0 | 1 | 0 | 3.86 | .300 | 1.29 | 6.5 | 5.7 | 10.6 | 11.2 | 8 | 5 | 5 | 1 | 7 | 13 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.73 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 89 | 28 | 20 | 10 | 9 | 6.23 | .328 | 1.44 | 10.1 | 2.8 | 8.9 | 134.1 | 151 | 97 | 93 | 30 | 42 | 133 | 0 | 0 | 0 | 0 | 6 | 4 | 5 | 4.96 |