| SP | deGrom, J.deGrom, Jacob $ >> | 33 | 2021 | R | 100 | 28 | 28 | 10 | 10 | 3.34 | .269 | 1.07 | 6.6 | 3.0 | 9.1 | 183.1 | 135 | 69 | 68 | 21 | 62 | 186 | 3 | 0 | 0 | 1 | 18 | 5 | 0 | 3.56 |
| SP | Arrieta, J.Arrieta, Jake $$ >> | 29 | 2015 | R | 93 | 27 | 27 | 8 | 13 | 5.18 | .327 | 1.42 | 9.4 | 3.4 | 6.7 | 165.0 | 173 | 95 | 95 | 26 | 62 | 123 | 1 | 0 | 0 | 0 | 14 | 5 | 2 | 4.78 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 85 | 27 | 27 | 9 | 7 | 5.95 | .351 | 1.59 | 11.1 | 3.3 | 5.3 | 137.2 | 169 | 95 | 91 | 23 | 50 | 81 | 0 | 0 | 0 | 0 | 6 | 4 | 4 | 5.18 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 79 | 26 | 26 | 6 | 11 | 4.10 | .311 | 1.31 | 9.4 | 2.4 | 6.3 | 182.0 | 190 | 90 | 83 | 21 | 49 | 127 | 8 | 0 | 0 | 0 | 13 | 8 | 1 | 4.04 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 25 | 25 | 9 | 11 | 3.81 | .288 | 1.20 | 8.0 | 2.8 | 4.6 | 179.1 | 159 | 82 | 76 | 13 | 56 | 91 | 4 | 0 | 0 | 1 | 13 | 3 | 4 | 3.92 |
| CL | Jansen, K.Jansen, Kenley † >> | 28 | 2016 | R | 97 | 55 | 0 | 3 | 5 | 2.25 | .229 | 0.89 | 5.8 | 2.3 | 8.2 | 64.0 | 41 | 17 | 16 | 4 | 16 | 58 | 0 | 30 | 3 | 0 | 0 | 0 | 0 | 2.75 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 41 | 0 | 3 | 4 | 3.72 | .329 | 1.43 | 7.3 | 5.6 | 8.1 | 48.1 | 39 | 20 | 20 | 5 | 30 | 43 | 0 | 1 | 0 | 0 | 0 | 2 | 3 | 4.56 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 36 | 0 | 1 | 2 | 3.29 | .315 | 1.38 | 6.6 | 5.9 | 8.3 | 38.1 | 28 | 15 | 14 | 4 | 25 | 35 | 0 | 1 | 0 | 0 | 0 | 0 | 5 | 4.50 |
| SP | Gooden, D.Gooden, Dwight >> | 21 | 1985 | R | 68 | 24 | 0 | 6 | 4 | 2.67 | .265 | 1.07 | 6.1 | 3.5 | 6.1 | 94.1 | 64 | 31 | 28 | 7 | 37 | 64 | 0 | 0 | 1 | 0 | 0 | 1 | 4 | 3.82 |