| SP | Tiant, L.Tiant, Luis $$ >> | 28 | 1968 | R | 97 | 32 | 32 | 12 | 12 | 3.81 | .312 | 1.35 | 8.2 | 4.0 | 8.2 | 207.2 | 188 | 96 | 88 | 24 | 92 | 189 | 3 | 0 | 0 | 2 | 18 | 2 | 7 | 4.04 |
| SP | Greinke, Z.Greinke, Zack # $$ >> | 32 | 2015 | R | 94 | 30 | 30 | 11 | 7 | 3.89 | .285 | 1.17 | 8.3 | 2.2 | 5.9 | 199.0 | 184 | 88 | 86 | 27 | 48 | 131 | 2 | 0 | 0 | 0 | 18 | 6 | 4 | 4.26 |
| SP | Maddux, G.Maddux, Greg $ >> | 29 | 1995 | R | 89 | 31 | 31 | 9 | 12 | 4.90 | .305 | 1.30 | 9.5 | 2.1 | 5.9 | 182.0 | 193 | 106 | 99 | 20 | 43 | 120 | 4 | 0 | 0 | 1 | 15 | 4 | 1 | 3.88 |
| SP | Sutton, D.Sutton, Don $ >> | 27 | 1972 | R | 82 | 30 | 30 | 11 | 11 | 4.83 | .320 | 1.38 | 9.6 | 2.9 | 5.0 | 193.2 | 205 | 109 | 104 | 30 | 63 | 107 | 5 | 0 | 0 | 2 | 12 | 6 | 3 | 4.98 |
| SP | Pfiester, J.Pfiester, Jack † >> | 28 | 1906 | L | 73 | 30 | 30 | 15 | 8 | 3.98 | .316 | 1.37 | 8.8 | 3.6 | 4.4 | 194.2 | 189 | 92 | 86 | 18 | 77 | 95 | 6 | 0 | 0 | 1 | 16 | 4 | 3 | 4.48 |
| CL | Doolittle, S.Doolittle, Sean # >> | 31 | 2018 | L | 98 | 68 | 0 | 6 | 8 | 5.43 | .297 | 1.27 | 9.1 | 2.4 | 7.5 | 64.2 | 65 | 42 | 39 | 10 | 17 | 53 | 0 | 41 | 12 | 0 | 0 | 0 | 2 | 4.17 |
| SU | Nathan, J.Nathan, Joe $$ >> | 32 | 2006 | R | 86 | 53 | 0 | 0 | 2 | 3.73 | .309 | 1.28 | 7.4 | 4.3 | 9.2 | 50.2 | 41 | 21 | 21 | 4 | 24 | 51 | 0 | 6 | 6 | 0 | 0 | 3 | 1 | 3.62 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 82 | 69 | 0 | 8 | 2 | 4.18 | .311 | 1.34 | 8.0 | 4.1 | 7.9 | 75.1 | 67 | 39 | 35 | 6 | 34 | 66 | 0 | 1 | 2 | 0 | 0 | 1 | 3 | 3.68 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 54 | 0 | 3 | 2 | 2.61 | .276 | 1.10 | 6.0 | 4.1 | 10.1 | 51.2 | 34 | 19 | 15 | 5 | 23 | 57 | 0 | 2 | 0 | 0 | 0 | 2 | 0 | 3.51 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 69 | 28 | 0 | 2 | 0 | 2.97 | .278 | 1.12 | 7.2 | 3.0 | 9.0 | 30.1 | 24 | 12 | 10 | 3 | 10 | 30 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.40 |