| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 4 | 4 | 0 | 1 | 4.63 | .286 | 1.20 | 9.0 | 2.0 | 9.8 | 23.1 | 23 | 12 | 12 | 2 | 5 | 25 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 2.61 |
| SP | Peralta, F.Peralta, Freddy >> | 29 | 2025 | R | 88 | 3 | 3 | 1 | 0 | 0.89 | .218 | 0.79 | 6.3 | 0.9 | 11.3 | 20.1 | 14 | 2 | 2 | 0 | 2 | 25 | 0 | 0 | 0 | 0 | 3 | 1 | 1 | 0.95 |
| SP | Imanaga, S.Imanaga, Shota >> | 31 | 2025 | L | 83 | 3 | 3 | 3 | 0 | 2.21 | .218 | 0.79 | 5.4 | 1.8 | 5.0 | 20.1 | 12 | 6 | 5 | 3 | 4 | 11 | 0 | 0 | 0 | 0 | 3 | 1 | 0 | 4.60 |
| SP | Taillon, J.Taillon, Jameson >> | 33 | 2025 | R | 76 | 3 | 3 | 0 | 0 | 5.74 | .365 | 1.72 | 11.4 | 4.8 | 7.8 | 15.2 | 19 | 11 | 10 | 3 | 8 | 13 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 5.47 |
| RP | Chapman, A.Chapman, Aroldis >> | 37 | 2025 | L | 100 | 9 | 0 | 2 | 0 | 1.35 | .259 | 1.05 | 6.2 | 3.5 | 11.8 | 13.1 | 9 | 4 | 2 | 1 | 5 | 17 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 2.54 |
| RP | Morejon, A.Morejon, Adrian >> | 26 | 2025 | L | 87 | 9 | 0 | 2 | 0 | 1.23 | .185 | 0.61 | 5.1 | 0.6 | 10.3 | 14.2 | 8 | 2 | 2 | 1 | 1 | 16 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 2.07 |
| RP | Sterner, J.Sterner, Justin >> | 28 | 2025 | R | 78 | 7 | 0 | 3 | 1 | 1.74 | .262 | 1.06 | 5.4 | 4.5 | 9.0 | 10.1 | 6 | 2 | 2 | 1 | 5 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.80 |
| RP | O'Brien, R.O'Brien, Riley >> | 30 | 2025 | R | 69 | 6 | 0 | 1 | 0 | 1.35 | .259 | 1.05 | 4.5 | 6.0 | 3.0 | 6.2 | 3 | 1 | 1 | 0 | 4 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.33 |
| RP | Pomeranz, D.Pomeranz, Drew >> | 36 | 2025 | L | 72 | 4 | 0 | 0 | 1 | 4.76 | .320 | 1.41 | 9.0 | 5.4 | 14.4 | 5.2 | 5 | 3 | 3 | 2 | 3 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.80 |