| SP | Skubal, T.Skubal, Tarik # >> | 28 | 2025 | L | 100 | 31 | 31 | 10 | 7 | 4.63 | .310 | 1.32 | 9.4 | 2.5 | 11.1 | 180.2 | 188 | 93 | 93 | 16 | 50 | 222 | 0 | 0 | 0 | 0 | 14 | 5 | 3 | 2.61 |
| SP | Peralta, F.Peralta, Freddy † >> | 29 | 2025 | R | 88 | 32 | 32 | 15 | 7 | 2.65 | .272 | 1.11 | 6.9 | 3.1 | 10.6 | 183.2 | 140 | 59 | 54 | 17 | 63 | 215 | 0 | 0 | 0 | 0 | 17 | 3 | 2 | 2.94 |
| SP | Imanaga, S.Imanaga, Shota >> | 31 | 2025 | L | 83 | 30 | 30 | 13 | 7 | 3.66 | .296 | 1.22 | 8.4 | 2.6 | 7.6 | 179.1 | 168 | 77 | 73 | 24 | 51 | 151 | 0 | 0 | 0 | 0 | 19 | 7 | 2 | 4.03 |
| SP | Taillon, J.Taillon, Jameson >> | 33 | 2025 | R | 76 | 30 | 30 | 6 | 9 | 7.01 | .361 | 1.67 | 12.0 | 3.0 | 6.8 | 145.0 | 194 | 116 | 113 | 28 | 48 | 110 | 0 | 0 | 0 | 0 | 8 | 4 | 2 | 5.07 |
| SP | Lauer, E.Lauer, Eric # >> | 30 | 2025 | L | 73 | 31 | 28 | 1 | 7 | 5.10 | .343 | 1.53 | 10.5 | 3.4 | 7.1 | 107.2 | 125 | 68 | 61 | 20 | 40 | 85 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 5.07 |
| RP | Chapman, A.Chapman, Aroldis † >> | 37 | 2025 | L | 100 | 90 | 0 | 14 | 1 | 1.78 | .243 | 0.93 | 5.4 | 3.1 | 12.1 | 126.2 | 75 | 29 | 25 | 8 | 43 | 169 | 0 | 4 | 0 | 0 | 0 | 4 | 5 | 2.26 |
| RP | Morejon, A.Morejon, Adrian † >> | 26 | 2025 | L | 87 | 95 | 0 | 9 | 8 | 3.12 | .285 | 1.14 | 8.1 | 2.1 | 8.8 | 124.0 | 112 | 47 | 43 | 6 | 29 | 121 | 0 | 9 | 3 | 0 | 0 | 7 | 4 | 2.55 |
| RP | Sterner, J.Sterner, Justin >> | 28 | 2025 | R | 78 | 73 | 0 | 8 | 3 | 3.45 | .316 | 1.34 | 7.7 | 4.3 | 8.8 | 86.0 | 74 | 34 | 33 | 13 | 41 | 84 | 0 | 5 | 3 | 0 | 0 | 4 | 2 | 4.58 |
| RP | O'Brien, R.O'Brien, Riley >> | 30 | 2025 | R | 69 | 70 | 0 | 7 | 3 | 2.13 | .291 | 1.18 | 6.9 | 3.8 | 6.8 | 80.1 | 61 | 19 | 19 | 5 | 34 | 60 | 0 | 7 | 2 | 0 | 0 | 4 | 8 | 3.74 |
| RP | Pomeranz, D.Pomeranz, Drew >> | 36 | 2025 | L | 72 | 62 | 0 | 3 | 3 | 2.84 | .272 | 1.12 | 7.8 | 2.3 | 10.8 | 76.0 | 66 | 26 | 24 | 9 | 19 | 91 | 0 | 2 | 3 | 0 | 0 | 0 | 1 | 2.89 |