| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 24 | 24 | 9 | 6 | 3.64 | .279 | 1.14 | 7.8 | 2.5 | 10.4 | 158.1 | 137 | 67 | 64 | 22 | 44 | 183 | 1 | 0 | 0 | 1 | 15 | 3 | 4 | 3.39 |
| SP | Peralta, F.Peralta, Freddy >> | 29 | 2025 | R | 88 | 23 | 23 | 6 | 9 | 4.23 | .317 | 1.36 | 7.7 | 4.5 | 10.0 | 121.1 | 104 | 59 | 57 | 15 | 61 | 134 | 0 | 0 | 0 | 0 | 6 | 4 | 3 | 4.01 |
| SP | Kirby, G.Kirby, George >> | 27 | 2025 | R | 65 | 23 | 23 | 5 | 13 | 7.25 | .366 | 1.69 | 11.5 | 3.8 | 9.4 | 111.2 | 142 | 92 | 90 | 22 | 47 | 116 | 0 | 0 | 0 | 0 | 4 | 4 | 5 | 4.86 |
| SP | Abbott, A.Abbott, Andrew >> | 26 | 2025 | L | 70 | 23 | 23 | 9 | 8 | 5.45 | .332 | 1.45 | 9.9 | 3.2 | 8.7 | 132.0 | 145 | 83 | 80 | 23 | 47 | 127 | 0 | 0 | 0 | 0 | 8 | 5 | 2 | 4.52 |
| CL | Hader, J.Hader, Josh † >> | 31 | 2025 | L | 100 | 41 | 0 | 1 | 5 | 2.40 | .262 | 1.02 | 6.6 | 2.6 | 8.6 | 41.1 | 30 | 11 | 11 | 3 | 12 | 39 | 0 | 21 | 3 | 0 | 0 | 2 | 1 | 3.07 |
| SU | Suarez, R.Suarez, Robert >> | 34 | 2025 | R | 91 | 41 | 0 | 1 | 2 | 2.76 | .243 | 0.96 | 6.4 | 2.4 | 10.0 | 45.2 | 32 | 14 | 14 | 8 | 12 | 50 | 0 | 4 | 3 | 0 | 0 | 0 | 0 | 3.89 |
| RP | Bednar, D.Bednar, David >> | 30 | 2025 | R | 80 | 68 | 0 | 6 | 3 | 4.41 | .300 | 1.28 | 8.5 | 3.1 | 11.6 | 69.1 | 65 | 34 | 34 | 10 | 24 | 89 | 0 | 0 | 2 | 0 | 0 | 0 | 3 | 3.35 |
| RP | Sousa, B.Sousa, Bennett >> | 30 | 2025 | L | 81 | 70 | 0 | 3 | 1 | 4.60 | .326 | 1.41 | 9.6 | 3.3 | 11.3 | 58.2 | 62 | 30 | 30 | 12 | 21 | 73 | 0 | 0 | 3 | 0 | 0 | 2 | 3 | 4.36 |
| RP | Strahm, M.Strahm, Matt >> | 33 | 2025 | L | 73 | 61 | 0 | 4 | 0 | 1.29 | .244 | 0.97 | 4.5 | 4.3 | 9.9 | 48.2 | 24 | 12 | 7 | 3 | 23 | 53 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 3.04 |
| RP | Megill, T.Megill, Trevor >> | 31 | 2025 | R | 71 | 50 | 0 | 0 | 2 | 2.60 | .307 | 1.29 | 7.3 | 4.3 | 11.3 | 52.0 | 42 | 18 | 15 | 3 | 25 | 65 | 0 | 0 | 2 | 0 | 0 | 2 | 2 | 2.81 |