| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 34 | 34 | 13 | 10 | 2.69 | .250 | 0.98 | 6.7 | 2.1 | 10.8 | 237.1 | 176 | 75 | 71 | 28 | 56 | 285 | 2 | 0 | 0 | 1 | 27 | 5 | 0 | 2.90 |
| SP | Berrios, J.Berrios, Jose >> | 31 | 2025 | R | 41 | 35 | 33 | 7 | 17 | 5.95 | .336 | 1.47 | 10.3 | 2.9 | 7.0 | 165.0 | 188 | 112 | 109 | 38 | 54 | 129 | 0 | 1 | 1 | 0 | 8 | 9 | 4 | 5.58 |
| SP | Walker, T.Walker, Taijuan >> | 32 | 2025 | R | 17 | 36 | 32 | 8 | 7 | 3.89 | .300 | 1.26 | 8.8 | 2.6 | 8.3 | 134.1 | 131 | 58 | 58 | 15 | 38 | 123 | 0 | 1 | 0 | 0 | 1 | 4 | 1 | 3.56 |
| SP | Matthews, Z.Matthews, Zebby >> | 25 | 2025 | R | 16 | 45 | 32 | 10 | 11 | 4.29 | .299 | 1.23 | 8.3 | 2.8 | 10.2 | 191.0 | 176 | 92 | 91 | 26 | 59 | 217 | 0 | 5 | 1 | 0 | 10 | 9 | 6 | 3.57 |
| RP | Bednar, D.Bednar, David † >> | 30 | 2025 | R | 88 | 101 | 0 | 14 | 6 | 3.59 | .272 | 1.12 | 7.4 | 2.7 | 10.3 | 138.0 | 114 | 57 | 55 | 21 | 41 | 158 | 0 | 8 | 6 | 0 | 0 | 0 | 6 | 3.58 |
| RP | Fairbanks, P.Fairbanks, Peter >> | 31 | 2025 | R | 81 | 102 | 0 | 4 | 5 | 3.55 | .290 | 1.20 | 7.1 | 3.7 | 8.4 | 134.1 | 106 | 54 | 53 | 23 | 55 | 125 | 0 | 9 | 5 | 0 | 0 | 4 | 6 | 4.69 |
| RP | Estevez, C.Estevez, Carlos >> | 32 | 2025 | R | 79 | 66 | 0 | 5 | 5 | 5.25 | .338 | 1.51 | 9.1 | 4.5 | 7.2 | 82.1 | 83 | 49 | 48 | 16 | 41 | 66 | 0 | 3 | 4 | 0 | 0 | 2 | 0 | 5.50 |
| RP | Kinley, T.Kinley, Tyler >> | 34 | 2025 | R | 74 | 92 | 0 | 8 | 3 | 2.58 | .252 | 0.98 | 5.0 | 3.8 | 10.1 | 111.2 | 62 | 33 | 32 | 11 | 47 | 124 | 0 | 9 | 2 | 0 | 0 | 4 | 5 | 3.43 |
| RP | Dominguez, S.Dominguez, Seranthony >> | 30 | 2025 | R | 72 | 65 | 0 | 4 | 1 | 3.90 | .314 | 1.34 | 6.2 | 6.0 | 9.9 | 80.2 | 55 | 35 | 35 | 9 | 53 | 88 | 0 | 4 | 0 | 0 | 0 | 3 | 7 | 4.36 |