| SP | Greinke, Z.Greinke, Zack >> | 32 | 2015 | R | 98 | 9 | 9 | 7 | 1 | 2.22 | .276 | 1.12 | 7.6 | 2.5 | 8.0 | 69.0 | 58 | 17 | 17 | 3 | 19 | 61 | 1 | 0 | 0 | 0 | 8 | 2 | 2 | 2.71 |
| SP | Hernandez, F.Hernandez, Felix >> | 29 | 2015 | R | 84 | 9 | 9 | 4 | 3 | 3.47 | .313 | 1.30 | 8.4 | 3.3 | 8.4 | 62.1 | 58 | 24 | 24 | 5 | 23 | 58 | 0 | 0 | 0 | 0 | 6 | 4 | 1 | 3.48 |
| SP | Buehrle, M.Buehrle, Mark >> | 36 | 2015 | L | 47 | 9 | 9 | 4 | 3 | 3.90 | .305 | 1.28 | 10.0 | 1.7 | 5.2 | 64.2 | 71 | 31 | 28 | 8 | 12 | 37 | 1 | 0 | 0 | 1 | 5 | 2 | 0 | 4.13 |
| SP | Foltynewicz, M.Foltynewicz, Michael >> | 23 | 2015 | R | 13 | 8 | 8 | 2 | 3 | 4.69 | .353 | 1.59 | 11.0 | 3.4 | 8.1 | 40.1 | 49 | 22 | 21 | 3 | 15 | 36 | 0 | 0 | 0 | 0 | 2 | 2 | 2 | 3.45 |
| RP | Qualls, C.Qualls, Chad >> | 37 | 2015 | R | 69 | 32 | 0 | 1 | 0 | 1.07 | .211 | 0.77 | 6.5 | 0.5 | 7.6 | 33.2 | 24 | 4 | 4 | 2 | 2 | 28 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 2.36 |
| RP | Rosenthal, T.Rosenthal, Trevor >> | 25 | 2015 | R | 60 | 25 | 0 | 1 | 2 | 3.33 | .314 | 1.37 | 9.3 | 3.0 | 8.0 | 27.0 | 28 | 11 | 10 | 0 | 9 | 24 | 0 | 5 | 2 | 0 | 0 | 0 | 4 | 2.22 |
| RP | Velasquez, V.Velasquez, Vince >> | 23 | 2015 | R | 58 | 8 | 0 | 1 | 1 | 2.84 | .269 | 1.03 | 9.8 | 0.0 | 10.5 | 12.2 | 13 | 6 | 4 | 2 | 0 | 14 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 3.08 |
| RP | Collmenter, J.Collmenter, Josh >> | 29 | 2015 | R | 39 | 1 | 0 | 1 | 0 | 0.00 | .125 | 0.43 | 0.0 | 4.5 | 9.0 | 2.1 | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.50 |
| RP | Andriese, M.Andriese, Matt >> | 25 | 2015 | R | 34 | 2 | 0 | 0 | 0 | 0.00 | .222 | 0.86 | 4.5 | 4.5 | 0.0 | 2.1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.50 |
| RP | Affeldt, J.Affeldt, Jeremy >> | 36 | 2015 | L | 6 | 33 | 0 | 0 | 3 | 6.30 | .381 | 1.80 | 12.2 | 4.1 | 5.4 | 20.0 | 27 | 14 | 14 | 7 | 9 | 12 | 0 | 2 | 2 | 0 | 0 | 1 | 0 | 7.85 |