| SP | Lester, J.Lester, Jon † >> | 32 | 2016 | L | 98 | 21 | 21 | 11 | 7 | 3.78 | .288 | 1.18 | 7.9 | 2.7 | 7.9 | 140.1 | 123 | 64 | 59 | 13 | 42 | 123 | 1 | 0 | 0 | 0 | 13 | 5 | 2 | 3.46 |
| SP | Rodriguez, E.Rodriguez, Eduardo >> | 23 | 2016 | L | 71 | 20 | 20 | 5 | 5 | 4.50 | .341 | 1.51 | 10.1 | 3.4 | 8.3 | 110.0 | 124 | 59 | 55 | 11 | 42 | 101 | 0 | 0 | 0 | 0 | 6 | 5 | 0 | 3.75 |
| SP | Eovaldi, N.Eovaldi, Nathan >> | 26 | 2016 | R | 53 | 19 | 19 | 4 | 9 | 5.36 | .347 | 1.57 | 10.3 | 3.8 | 9.0 | 99.0 | 113 | 62 | 59 | 19 | 42 | 99 | 0 | 0 | 0 | 0 | 5 | 3 | 4 | 4.86 |
| SP | Surkamp, E.Surkamp, Eric >> | 28 | 2016 | L | 2 | 14 | 14 | 1 | 8 | 7.74 | .369 | 1.74 | 11.7 | 3.9 | 7.6 | 57.0 | 74 | 51 | 49 | 11 | 25 | 48 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 5.19 |
| RP | Miller, A.Miller, Andrew >> | 31 | 2016 | L | 100 | 54 | 0 | 5 | 1 | 2.34 | .254 | 0.98 | 7.0 | 1.8 | 11.9 | 69.1 | 54 | 23 | 18 | 4 | 14 | 91 | 0 | 2 | 2 | 0 | 0 | 3 | 0 | 1.86 |
| RP | Blevins, J.Blevins, Jerry >> | 33 | 2016 | L | 73 | 40 | 0 | 1 | 0 | 2.36 | .263 | 1.07 | 7.3 | 2.4 | 10.7 | 42.0 | 34 | 12 | 11 | 1 | 11 | 50 | 0 | 5 | 0 | 0 | 0 | 0 | 0 | 1.71 |
| RP | Grilli, J.Grilli, Jason >> | 40 | 2016 | R | 72 | 50 | 0 | 2 | 3 | 3.91 | .303 | 1.28 | 8.0 | 3.5 | 12.1 | 46.0 | 41 | 21 | 20 | 8 | 18 | 62 | 0 | 4 | 2 | 0 | 0 | 1 | 0 | 3.80 |
| RP | Robertson, D.Robertson, David # >> | 31 | 2016 | R | 55 | 28 | 0 | 0 | 5 | 5.34 | .323 | 1.40 | 8.0 | 4.8 | 10.0 | 28.2 | 25 | 17 | 17 | 6 | 15 | 31 | 0 | 5 | 1 | 0 | 0 | 1 | 1 | 5.29 |