| SP | Scherzer, M.Scherzer, Max † >> | 32 | 2016 | R | 100 | 20 | 20 | 9 | 8 | 2.60 | .256 | 0.99 | 6.7 | 2.2 | 9.4 | 149.0 | 111 | 50 | 43 | 17 | 36 | 156 | 4 | 0 | 0 | 3 | 15 | 7 | 2 | 3.26 |
| SP | Tanaka, M.Tanaka, Masahiro >> | 27 | 2016 | R | 88 | 20 | 20 | 10 | 8 | 3.22 | .297 | 1.27 | 9.1 | 2.4 | 8.0 | 134.0 | 135 | 52 | 48 | 10 | 35 | 119 | 1 | 0 | 0 | 0 | 14 | 0 | 1 | 2.98 |
| SP | Guerra, J.Guerra, Junior # >> | 31 | 2016 | R | 91 | 20 | 20 | 6 | 7 | 3.42 | .305 | 1.30 | 8.4 | 3.4 | 6.9 | 131.2 | 122 | 58 | 50 | 19 | 49 | 101 | 1 | 0 | 0 | 0 | 12 | 2 | 6 | 4.51 |
| SP | Perdomo, L.Perdomo, Luis # >> | 23 | 2016 | R | 10 | 15 | 15 | 3 | 6 | 6.24 | .354 | 1.61 | 11.3 | 3.2 | 8.0 | 62.0 | 78 | 43 | 43 | 14 | 22 | 55 | 0 | 0 | 0 | 0 | 0 | 2 | 4 | 5.32 |
| RP | Buchter, R.Buchter, Ryan >> | 29 | 2016 | L | 96 | 50 | 0 | 5 | 1 | 2.30 | .290 | 1.18 | 6.5 | 4.2 | 11.0 | 58.2 | 42 | 16 | 15 | 9 | 27 | 71 | 0 | 8 | 2 | 0 | 0 | 3 | 2 | 4.12 |
| RP | Devenski, C.Devenski, Chris >> | 25 | 2016 | R | 93 | 31 | 0 | 2 | 3 | 2.67 | .254 | 0.97 | 6.2 | 2.7 | 8.0 | 60.2 | 41 | 18 | 18 | 2 | 18 | 53 | 0 | 7 | 2 | 0 | 0 | 3 | 1 | 2.72 |
| RP | Rondon, H.Rondon, Hector >> | 28 | 2016 | R | 87 | 20 | 0 | 2 | 0 | 6.66 | .360 | 1.68 | 11.6 | 3.8 | 10.9 | 24.1 | 31 | 18 | 18 | 3 | 10 | 29 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.46 |
| RP | Cedeno, X.Cedeno, Xavier >> | 29 | 2016 | L | 68 | 12 | 0 | 1 | 0 | 2.93 | .292 | 1.11 | 8.4 | 1.8 | 10.2 | 15.1 | 14 | 5 | 5 | 1 | 3 | 17 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 2.60 |
| RP | Clippard, T.Clippard, Tyler >> | 31 | 2016 | R | 64 | 12 | 0 | 0 | 1 | 1.38 | .291 | 1.15 | 6.2 | 4.2 | 9.0 | 13.0 | 9 | 2 | 2 | 1 | 6 | 13 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 3.62 |
| RP | Storen, D.Storen, Drew >> | 28 | 2016 | R | 36 | 12 | 0 | 3 | 0 | 1.38 | .278 | 1.08 | 6.2 | 3.5 | 6.2 | 13.0 | 9 | 2 | 2 | 1 | 5 | 9 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.00 |