| SP | Beachy, B.Beachy, Brandon >> | 25 | 2012 | R | 100 | 25 | 25 | 10 | 10 | 2.65 | .281 | 1.15 | 6.6 | 3.7 | 7.3 | 170.0 | 125 | 56 | 50 | 9 | 70 | 137 | 1 | 0 | 0 | 0 | 16 | 4 | 8 | 3.38 |
| SP | Blackley, T.Blackley, Travis >> | 30 | 2012 | L | 83 | 25 | 25 | 9 | 10 | 3.81 | .286 | 1.18 | 7.7 | 3.0 | 6.7 | 134.2 | 114 | 63 | 57 | 22 | 45 | 100 | 0 | 0 | 0 | 0 | 8 | 3 | 2 | 4.72 |
| SP | Marcum, S.Marcum, Shaun # >> | 31 | 2012 | R | 71 | 23 | 23 | 8 | 8 | 3.07 | .291 | 1.21 | 7.8 | 3.1 | 8.5 | 138.0 | 120 | 53 | 47 | 11 | 47 | 130 | 0 | 0 | 0 | 0 | 15 | 3 | 5 | 3.24 |
| SP | Karstens, J.Karstens, Jeff >> | 30 | 2012 | R | 76 | 25 | 25 | 6 | 12 | 3.70 | .284 | 1.16 | 8.4 | 2.1 | 6.2 | 150.2 | 140 | 65 | 62 | 14 | 35 | 103 | 0 | 0 | 0 | 0 | 14 | 4 | 1 | 3.62 |
| SP | Scherzer, M.Scherzer, Max >> | 28 | 2012 | R | 68 | 24 | 24 | 8 | 8 | 4.69 | .319 | 1.36 | 9.1 | 3.1 | 11.7 | 132.1 | 134 | 70 | 69 | 21 | 46 | 172 | 0 | 0 | 0 | 0 | 9 | 6 | 2 | 3.64 |
| RP | Peralta, J.Peralta, Joel >> | 36 | 2012 | R | 95 | 63 | 0 | 4 | 0 | 3.92 | .316 | 1.36 | 9.1 | 3.2 | 9.6 | 85.0 | 86 | 37 | 37 | 6 | 30 | 91 | 0 | 4 | 4 | 0 | 0 | 2 | 7 | 2.91 |
| RP | Hernandez, D.Hernandez, David >> | 27 | 2012 | R | 95 | 63 | 0 | 0 | 1 | 2.04 | .251 | 0.96 | 4.7 | 4.0 | 11.9 | 83.2 | 43 | 19 | 19 | 4 | 37 | 110 | 0 | 10 | 1 | 0 | 0 | 4 | 2 | 2.46 |
| RP | Belisario, R.Belisario, Ronald >> | 30 | 2012 | R | 91 | 46 | 0 | 7 | 3 | 2.61 | .290 | 1.21 | 7.4 | 3.5 | 6.4 | 62.0 | 51 | 19 | 18 | 8 | 24 | 44 | 0 | 3 | 3 | 0 | 0 | 1 | 1 | 4.47 |
| RP | Clippard, T.Clippard, Tyler # >> | 27 | 2012 | R | 81 | 37 | 0 | 3 | 5 | 3.92 | .287 | 1.19 | 6.8 | 4.0 | 10.5 | 41.1 | 31 | 18 | 18 | 4 | 18 | 48 | 0 | 5 | 3 | 0 | 0 | 1 | 1 | 3.32 |
| RP | Walden, J.Walden, Jordan >> | 24 | 2012 | R | 52 | 26 | 0 | 3 | 0 | 4.62 | .361 | 1.66 | 8.6 | 6.5 | 10.8 | 25.1 | 24 | 14 | 13 | 2 | 18 | 30 | 0 | 5 | 0 | 0 | 0 | 1 | 3 | 3.92 |