| SP | Roark, T.Roark, Tanner >> | 29 | 2016 | R | 87 | 20 | 20 | 10 | 8 | 4.02 | .286 | 1.17 | 7.5 | 3.0 | 7.2 | 123.0 | 103 | 57 | 55 | 12 | 41 | 99 | 1 | 0 | 0 | 1 | 11 | 4 | 3 | 3.76 |
| SP | Buchholz, C.Buchholz, Clay # >> | 32 | 2016 | R | 54 | 19 | 19 | 1 | 6 | 3.89 | .298 | 1.25 | 8.9 | 2.3 | 7.3 | 81.0 | 80 | 37 | 35 | 8 | 21 | 66 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 3.51 |
| SP | Friedrich, C.Friedrich, Christian # >> | 28 | 2016 | R | 42 | 21 | 18 | 4 | 12 | 6.67 | .390 | 1.87 | 12.8 | 4.1 | 8.7 | 87.2 | 124 | 71 | 65 | 11 | 40 | 84 | 0 | 0 | 0 | 0 | 4 | 4 | 6 | 4.23 |
| SP | Nelson, J.Nelson, Jimmy >> | 27 | 2016 | R | 30 | 19 | 18 | 5 | 9 | 4.67 | .352 | 1.60 | 10.1 | 4.3 | 7.9 | 96.1 | 108 | 56 | 50 | 15 | 46 | 84 | 0 | 0 | 0 | 0 | 7 | 3 | 5 | 4.81 |
| SP | Wacha, M.Wacha, Michael >> | 24 | 2016 | R | 26 | 18 | 15 | 5 | 8 | 5.51 | .350 | 1.54 | 10.6 | 3.4 | 7.4 | 81.2 | 95 | 52 | 50 | 12 | 31 | 67 | 0 | 0 | 0 | 0 | 4 | 6 | 2 | 4.64 |
| CL | Blanton, J.Blanton, Joe >> | 36 | 2016 | R | 91 | 43 | 0 | 2 | 4 | 3.28 | .293 | 1.22 | 7.8 | 3.3 | 9.2 | 46.2 | 40 | 19 | 17 | 4 | 17 | 47 | 0 | 16 | 1 | 0 | 0 | 1 | 1 | 3.26 |
| RP | Benoit, J.Benoit, Joaquin >> | 39 | 2016 | R | 69 | 58 | 0 | 2 | 2 | 5.02 | .325 | 1.42 | 8.5 | 4.4 | 10.8 | 66.1 | 62 | 41 | 37 | 10 | 32 | 79 | 0 | 1 | 3 | 0 | 0 | 2 | 2 | 4.12 |
| RP | Barrett, J.Barrett, Jake >> | 24 | 2016 | R | 65 | 51 | 0 | 4 | 1 | 2.83 | .320 | 1.38 | 7.6 | 4.9 | 8.7 | 57.1 | 48 | 22 | 18 | 4 | 31 | 55 | 0 | 0 | 1 | 0 | 0 | 2 | 5 | 3.72 |