| SP | deGrom, J.deGrom, Jacob † # >> | 28 | 2016 | R | 78 | 21 | 21 | 10 | 7 | 3.92 | .308 | 1.28 | 9.1 | 2.4 | 9.6 | 133.1 | 135 | 64 | 58 | 10 | 35 | 142 | 2 | 0 | 0 | 0 | 12 | 8 | 5 | 2.81 |
| SP | Paxton, J.Paxton, James >> | 27 | 2016 | L | 50 | 21 | 21 | 6 | 4 | 4.74 | .321 | 1.40 | 9.5 | 3.2 | 8.2 | 114.0 | 120 | 60 | 60 | 8 | 40 | 104 | 0 | 0 | 0 | 0 | 10 | 2 | 1 | 3.19 |
| SP | Sanchez, A.Sanchez, Anibal >> | 32 | 2016 | R | 32 | 20 | 20 | 0 | 7 | 5.17 | .329 | 1.37 | 9.6 | 2.9 | 7.1 | 62.2 | 66 | 39 | 36 | 7 | 20 | 49 | 0 | 0 | 0 | 0 | 0 | 6 | 0 | 4.15 |
| SP | Clemens, P.Clemens, Paul >> | 28 | 2016 | R | 46 | 19 | 18 | 1 | 5 | 3.97 | .308 | 1.26 | 7.7 | 3.6 | 7.5 | 79.1 | 68 | 37 | 35 | 6 | 32 | 66 | 0 | 1 | 0 | 0 | 1 | 6 | 2 | 3.76 |
| SP | Harrell, L.Harrell, Lucas >> | 31 | 2016 | R | 38 | 15 | 11 | 3 | 6 | 3.13 | .290 | 1.21 | 6.9 | 4.1 | 8.7 | 60.1 | 46 | 21 | 21 | 5 | 27 | 58 | 0 | 0 | 1 | 0 | 0 | 1 | 3 | 3.55 |
| CL | Kelley, S.Kelley, Shawn >> | 32 | 2016 | R | 98 | 48 | 0 | 2 | 3 | 3.25 | .301 | 1.23 | 9.3 | 1.9 | 11.6 | 52.2 | 54 | 21 | 19 | 1 | 11 | 67 | 0 | 17 | 2 | 0 | 0 | 3 | 1 | 1.48 |
| RP | Uehara, K.Uehara, Koji † >> | 41 | 2016 | R | 96 | 55 | 0 | 13 | 1 | 3.04 | .272 | 1.11 | 6.8 | 3.2 | 11.3 | 74.0 | 56 | 25 | 25 | 5 | 26 | 93 | 0 | 1 | 2 | 0 | 0 | 1 | 3 | 2.46 |
| RP | Betances, D.Betances, Dellin >> | 28 | 2016 | R | 88 | 49 | 0 | 2 | 0 | 3.99 | .307 | 1.30 | 6.8 | 5.0 | 13.3 | 58.2 | 44 | 29 | 26 | 4 | 32 | 86 | 0 | 2 | 3 | 0 | 0 | 2 | 4 | 2.69 |
| RP | Vincent, N.Vincent, Nick >> | 29 | 2016 | R | 77 | 36 | 0 | 2 | 2 | 2.45 | .316 | 1.32 | 8.2 | 3.8 | 10.7 | 47.2 | 43 | 13 | 13 | 2 | 20 | 56 | 0 | 0 | 3 | 0 | 0 | 3 | 0 | 2.64 |
| RP | Robles, H.Robles, Hansel >> | 25 | 2016 | R | 50 | 44 | 0 | 1 | 3 | 4.50 | .324 | 1.44 | 9.4 | 3.6 | 11.3 | 48.0 | 50 | 25 | 24 | 8 | 19 | 60 | 0 | 3 | 3 | 0 | 0 | 0 | 2 | 3.85 |
| RP | Quackenbush, K.Quackenbush, Kevin >> | 27 | 2016 | R | 48 | 38 | 0 | 0 | 3 | 3.24 | .286 | 1.18 | 6.6 | 4.2 | 8.8 | 41.2 | 30 | 16 | 15 | 4 | 19 | 40 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 3.78 |