| SP | Strasburg, S.Strasburg, Stephen >> | 27 | 2016 | R | 96 | 21 | 21 | 4 | 12 | 4.05 | .290 | 1.18 | 8.3 | 2.4 | 10.4 | 133.1 | 122 | 64 | 60 | 19 | 35 | 153 | 0 | 0 | 0 | 0 | 9 | 6 | 1 | 3.48 |
| SP | Kazmir, S.Kazmir, Scott >> | 32 | 2016 | L | 57 | 20 | 20 | 8 | 7 | 4.06 | .314 | 1.35 | 8.7 | 3.6 | 8.5 | 106.1 | 102 | 63 | 48 | 12 | 42 | 100 | 0 | 0 | 0 | 0 | 7 | 2 | 0 | 3.83 |
| SP | Duffey, T.Duffey, Tyler >> | 25 | 2016 | R | 22 | 20 | 19 | 5 | 11 | 7.40 | .370 | 1.73 | 12.8 | 2.8 | 7.1 | 86.1 | 122 | 79 | 71 | 19 | 27 | 68 | 0 | 0 | 0 | 0 | 3 | 3 | 12 | 5.34 |
| SP | Cosart, J.Cosart, Jarred >> | 26 | 2016 | R | 14 | 19 | 19 | 0 | 11 | 6.28 | .407 | 2.02 | 11.7 | 6.5 | 7.1 | 77.1 | 100 | 58 | 54 | 8 | 56 | 61 | 0 | 0 | 0 | 0 | 0 | 3 | 4 | 5.06 |
| RP | Rivero, F.Rivero, Felipe >> | 24 | 2016 | L | 63 | 76 | 0 | 2 | 1 | 3.90 | .301 | 1.19 | 7.4 | 3.4 | 10.2 | 80.2 | 66 | 36 | 35 | 9 | 30 | 91 | 0 | 6 | 3 | 0 | 0 | 8 | 4 | 3.61 |
| RP | Biagini, J.Biagini, Joe >> | 26 | 2016 | R | 41 | 69 | 0 | 4 | 1 | 4.32 | .306 | 1.29 | 8.3 | 3.4 | 7.8 | 85.1 | 78 | 43 | 41 | 9 | 32 | 74 | 0 | 4 | 3 | 0 | 0 | 3 | 4 | 3.87 |