| SP | Santana, E.Santana, Ervin >> | 33 | 2016 | R | 75 | 21 | 21 | 4 | 12 | 4.41 | .299 | 1.25 | 9.1 | 2.1 | 8.2 | 130.2 | 132 | 68 | 64 | 11 | 31 | 119 | 1 | 0 | 0 | 0 | 12 | 4 | 9 | 3.08 |
| SP | Colon, B.Colon, Bartolo # >> | 43 | 2016 | R | 61 | 20 | 20 | 4 | 8 | 4.58 | .311 | 1.31 | 9.8 | 2.1 | 7.2 | 118.0 | 128 | 61 | 60 | 15 | 27 | 95 | 0 | 0 | 0 | 0 | 9 | 5 | 0 | 3.86 |
| SP | Vogelsong, R.Vogelsong, Ryan >> | 39 | 2016 | R | 38 | 19 | 19 | 2 | 2 | 3.54 | .301 | 1.28 | 8.4 | 3.2 | 7.0 | 73.2 | 68 | 29 | 29 | 8 | 26 | 57 | 0 | 0 | 0 | 0 | 0 | 1 | 4 | 3.97 |
| SP | Chacin, J.Chacin, Jhoulys >> | 28 | 2016 | R | 37 | 19 | 19 | 3 | 6 | 5.52 | .321 | 1.36 | 10.0 | 2.3 | 7.6 | 88.0 | 98 | 54 | 54 | 12 | 22 | 74 | 0 | 0 | 0 | 0 | 2 | 5 | 3 | 4.01 |
| CL | Liberatore, A.Liberatore, Adam † >> | 29 | 2016 | L | 75 | 44 | 0 | 1 | 1 | 2.81 | .294 | 1.20 | 6.8 | 4.2 | 10.1 | 41.2 | 31 | 16 | 13 | 2 | 19 | 46 | 0 | 27 | 3 | 0 | 0 | 2 | 1 | 2.93 |
| RP | Casilla, S.Casilla, Santiago >> | 36 | 2016 | R | 72 | 53 | 0 | 10 | 5 | 2.96 | .268 | 1.07 | 6.7 | 3.0 | 12.0 | 70.0 | 52 | 23 | 23 | 11 | 23 | 93 | 0 | 1 | 1 | 0 | 0 | 2 | 5 | 3.46 |
| RP | Guerra, D.Guerra, Deolis >> | 27 | 2016 | R | 64 | 50 | 0 | 7 | 5 | 3.02 | .235 | 0.87 | 7.0 | 0.9 | 6.3 | 80.1 | 62 | 27 | 27 | 4 | 8 | 56 | 0 | 0 | 2 | 0 | 0 | 4 | 1 | 2.70 |
| RP | Cabrera, M.Cabrera, Mauricio >> | 22 | 2016 | R | 57 | 47 | 0 | 5 | 3 | 3.21 | .295 | 1.24 | 8.5 | 2.7 | 8.3 | 53.1 | 50 | 26 | 19 | 3 | 16 | 49 | 0 | 0 | 2 | 0 | 0 | 1 | 1 | 2.85 |
| RP | Ramirez, E.Ramirez, Erasmo # >> | 26 | 2016 | R | 40 | 36 | 0 | 3 | 1 | 5.87 | .321 | 1.36 | 9.8 | 2.5 | 7.0 | 53.2 | 58 | 37 | 35 | 5 | 15 | 41 | 0 | 1 | 2 | 0 | 0 | 3 | 2 | 3.70 |
| RP | Lyles, J.Lyles, Jordan >> | 25 | 2016 | R | 6 | 31 | 0 | 2 | 0 | 4.14 | .333 | 1.48 | 10.3 | 3.1 | 7.0 | 41.1 | 47 | 25 | 19 | 3 | 14 | 32 | 0 | 1 | 1 | 0 | 0 | 1 | 4 | 3.49 |