| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 41 | 41 | 11 | 14 | 2.65 | .241 | 0.94 | 6.4 | 2.0 | 10.1 | 275.0 | 197 | 85 | 81 | 30 | 62 | 310 | 4 | 0 | 0 | 2 | 32 | 3 | 0 | 2.87 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 85 | 41 | 41 | 6 | 18 | 4.39 | .325 | 1.41 | 9.4 | 3.4 | 6.6 | 227.2 | 237 | 119 | 111 | 34 | 85 | 167 | 0 | 0 | 0 | 0 | 21 | 7 | 1 | 4.69 |
| SP | Arrieta, J.Arrieta, Jake >> | 30 | 2016 | R | 82 | 40 | 40 | 4 | 20 | 4.84 | .318 | 1.37 | 8.1 | 4.2 | 7.6 | 223.1 | 201 | 122 | 120 | 43 | 105 | 189 | 1 | 0 | 0 | 0 | 23 | 6 | 11 | 5.30 |
| RP | Miller, A.Miller, Andrew >> | 31 | 2016 | L | 100 | 108 | 0 | 2 | 2 | 3.03 | .275 | 1.12 | 7.9 | 2.2 | 9.8 | 107.0 | 94 | 36 | 36 | 8 | 26 | 117 | 0 | 0 | 2 | 0 | 0 | 2 | 3 | 2.57 |
| RP | Edwards, C.Edwards, Carl >> | 24 | 2016 | R | 100 | 116 | 0 | 7 | 7 | 3.63 | .253 | 0.98 | 5.8 | 3.1 | 10.1 | 91.2 | 59 | 39 | 37 | 11 | 31 | 102 | 0 | 2 | 4 | 0 | 0 | 3 | 9 | 3.45 |
| RP | Chapman, A.Chapman, Aroldis >> | 28 | 2016 | L | 98 | 93 | 0 | 3 | 3 | 3.68 | .299 | 1.26 | 6.7 | 4.8 | 10.4 | 58.2 | 43 | 26 | 24 | 7 | 31 | 67 | 0 | 4 | 2 | 0 | 0 | 1 | 9 | 3.91 |
| RP | Cahill, T.Cahill, Trevor >> | 28 | 2016 | R | 57 | 65 | 0 | 3 | 5 | 4.05 | .341 | 1.45 | 8.0 | 5.1 | 8.4 | 60.0 | 53 | 30 | 27 | 7 | 34 | 56 | 0 | 5 | 1 | 0 | 0 | 6 | 4 | 4.65 |
| RP | Rondon, H.Rondon, Hector >> | 28 | 2016 | R | 79 | 42 | 0 | 5 | 3 | 4.55 | .325 | 1.45 | 10.3 | 2.8 | 9.5 | 55.1 | 63 | 29 | 28 | 6 | 17 | 58 | 0 | 2 | 0 | 0 | 0 | 0 | 2 | 3.24 |
| SP | Hammel, J.Hammel, Jason >> | 34 | 2016 | R | 58 | 12 | 0 | 0 | 2 | 9.37 | .417 | 2.02 | 13.5 | 5.1 | 5.6 | 16.1 | 24 | 17 | 17 | 6 | 9 | 10 | 0 | 2 | 0 | 0 | 0 | 2 | 2 | 8.69 |