| SP | Scherzer, M.Scherzer, Max >> | 37 | 2021 | R | 98 | 43 | 43 | 13 | 19 | 3.91 | .291 | 1.20 | 8.2 | 2.6 | 9.1 | 262.2 | 238 | 118 | 114 | 36 | 77 | 266 | 2 | 0 | 0 | 0 | 25 | 8 | 2 | 3.73 |
| SP | Bauer, T.Bauer, Trevor >> | 30 | 2021 | R | 90 | 43 | 43 | 15 | 14 | 3.98 | .317 | 1.37 | 8.0 | 4.3 | 9.9 | 246.2 | 220 | 119 | 109 | 29 | 117 | 270 | 0 | 0 | 0 | 0 | 24 | 7 | 8 | 3.85 |
| SP | Kershaw, C.Kershaw, Clayton >> | 33 | 2021 | L | 80 | 38 | 38 | 10 | 13 | 4.56 | .299 | 1.26 | 8.7 | 2.6 | 9.4 | 201.1 | 195 | 110 | 102 | 35 | 59 | 211 | 0 | 0 | 0 | 0 | 18 | 4 | 5 | 4.10 |
| SP | Buehler, W.Buehler, Walker >> | 26 | 2021 | R | 89 | 4 | 4 | 0 | 2 | 8.68 | .391 | 1.88 | 14.5 | 3.0 | 11.0 | 18.2 | 29 | 18 | 18 | 4 | 6 | 22 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 4.61 |
| CL | Rivera, M.Rivera, Mariano † >> | 39 | 2008 | R | 98 | 66 | 0 | 5 | 6 | 1.86 | .228 | 0.86 | 6.7 | 1.1 | 7.5 | 67.2 | 50 | 15 | 14 | 5 | 8 | 56 | 0 | 44 | 3 | 0 | 0 | 2 | 0 | 2.75 |
| SU | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 97 | 65 | 0 | 2 | 2 | 3.18 | .290 | 1.20 | 6.0 | 4.8 | 9.9 | 79.1 | 53 | 31 | 28 | 9 | 42 | 87 | 0 | 3 | 5 | 0 | 0 | 2 | 10 | 3.95 |
| RP | Nelson, J.Nelson, Jimmy >> | 32 | 2021 | R | 97 | 96 | 0 | 8 | 1 | 2.99 | .270 | 1.07 | 5.6 | 4.0 | 11.7 | 99.1 | 62 | 34 | 33 | 6 | 44 | 129 | 0 | 1 | 4 | 0 | 0 | 4 | 14 | 2.64 |
| RP | Jansen, K.Jansen, Kenley >> | 33 | 2021 | R | 89 | 60 | 0 | 3 | 2 | 3.30 | .299 | 1.24 | 7.0 | 4.4 | 9.4 | 62.2 | 48 | 23 | 23 | 7 | 30 | 65 | 0 | 3 | 0 | 0 | 0 | 2 | 2 | 3.92 |
| RP | Knebel, C.Knebel, Corey >> | 29 | 2021 | R | 89 | 37 | 0 | 2 | 3 | 3.13 | .258 | 1.04 | 6.7 | 2.9 | 8.4 | 31.2 | 23 | 12 | 11 | 4 | 10 | 29 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 3.77 |
| RP | Treinen, B.Treinen, Blake >> | 33 | 2021 | R | 90 | 17 | 0 | 2 | 0 | 3.60 | .286 | 1.20 | 6.0 | 4.8 | 10.2 | 15.0 | 10 | 6 | 6 | 3 | 8 | 17 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 4.93 |
| RP | Reyes, C.Reyes, Carlos >> | 29 | 1998 | R | 56 | 12 | 0 | 2 | 1 | 1.32 | .293 | 1.17 | 6.9 | 4.2 | 6.2 | 13.2 | 10 | 2 | 2 | 0 | 6 | 9 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 3.23 |
| RP | Bickford, P.Bickford, Phil >> | 25 | 2021 | R | 85 | 7 | 0 | 1 | 0 | 0.00 | .184 | 0.68 | 3.6 | 2.7 | 5.4 | 10.1 | 4 | 0 | 0 | 0 | 3 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.70 |
| SP | Spencer, S.Spencer, Stan >> | 30 | 1998 | R | 63 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |