| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 4 | 4 | 3 | 1 | 1.67 | .264 | 1.07 | 5.3 | 4.3 | 8.0 | 27.0 | 16 | 5 | 5 | 0 | 13 | 24 | 1 | 0 | 0 | 1 | 3 | 0 | 1 | 2.67 |
| SP | Carpenter, C.Carpenter, Chris >> | 34 | 2009 | R | 80 | 4 | 4 | 2 | 0 | 4.76 | .320 | 1.41 | 10.2 | 2.9 | 4.1 | 22.2 | 25 | 12 | 12 | 3 | 7 | 10 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 4.82 |
| SP | Pettitte, A.Pettitte, Andy >> | 33 | 2005 | L | 77 | 4 | 4 | 2 | 1 | 5.96 | .340 | 1.54 | 9.8 | 4.5 | 4.9 | 22.2 | 24 | 18 | 15 | 5 | 11 | 12 | 0 | 0 | 0 | 0 | 2 | 0 | 2 | 6.36 |
| SP | Burkett, J.Burkett, John >> | 37 | 2001 | R | 50 | 4 | 4 | 0 | 1 | 4.00 | .349 | 1.61 | 11.0 | 3.5 | 3.0 | 18.0 | 22 | 8 | 8 | 1 | 7 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.22 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 26 | 2006 | R | 93 | 13 | 0 | 1 | 0 | 5.68 | .296 | 1.26 | 10.5 | 1.5 | 12.8 | 12.2 | 14 | 8 | 8 | 4 | 2 | 17 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 5.00 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 89 | 12 | 0 | 0 | 0 | 0.79 | .292 | 0.88 | 4.9 | 3.3 | 5.7 | 11.1 | 6 | 1 | 1 | 0 | 4 | 7 | 0 | 1 | 0 | 0 | 0 | 4 | 0 | 3.91 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 86 | 11 | 0 | 0 | 0 | 2.61 | .205 | 0.68 | 5.4 | 0.9 | 9.0 | 10.1 | 6 | 3 | 3 | 1 | 1 | 10 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 2.90 |
| RP | Hoffman, T.Hoffman, Trevor >> | 42 | 2009 | R | 70 | 11 | 0 | 3 | 0 | 2.61 | .262 | 1.06 | 8.1 | 1.8 | 6.3 | 10.1 | 9 | 3 | 3 | 1 | 2 | 7 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 3.50 |
| RP | Cormier, R.Cormier, Rheal >> | 36 | 2003 | L | 62 | 9 | 0 | 0 | 1 | 7.20 | .444 | 2.20 | 14.4 | 5.4 | 1.8 | 5.0 | 8 | 5 | 4 | 2 | 3 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 10.20 |
| RP | Okajima, H.Okajima, Hideki >> | 32 | 2007 | L | 52 | 8 | 0 | 1 | 2 | 3.52 | .361 | 1.57 | 10.3 | 5.1 | 6.4 | 7.2 | 8 | 3 | 3 | 2 | 4 | 5 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 7.43 |
| SP | Hernandez, L.Hernandez, Livan >> | 28 | 2003 | R | 10 | 4 | 0 | 1 | 0 | 3.55 | .309 | 1.34 | 11.3 | 1.5 | 7.5 | 12.2 | 15 | 5 | 5 | 1 | 2 | 10 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2.92 |