| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 95 | 14 | 14 | 4 | 3 | 3.22 | .272 | 1.10 | 6.3 | 3.6 | 10.8 | 81.0 | 57 | 29 | 29 | 7 | 32 | 97 | 0 | 0 | 0 | 0 | 6 | 2 | 0 | 2.99 |
| SP | Alvarez, W.Alvarez, Wilson >> | 33 | 2003 | L | 75 | 14 | 14 | 0 | 7 | 7.08 | .364 | 1.70 | 11.7 | 3.8 | 8.5 | 54.2 | 70 | 43 | 43 | 13 | 23 | 51 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 5.57 |
| SP | Mussina, M.Mussina, Mike # >> | 33 | 2001 | R | 68 | 14 | 14 | 3 | 5 | 4.87 | .322 | 1.42 | 10.4 | 2.4 | 9.3 | 85.0 | 98 | 47 | 46 | 12 | 23 | 88 | 0 | 0 | 0 | 0 | 10 | 0 | 5 | 3.58 |
| SP | Clement, M.Clement, Matt >> | 28 | 2002 | R | 55 | 13 | 13 | 4 | 5 | 4.92 | .343 | 1.53 | 9.5 | 4.4 | 8.8 | 78.2 | 82 | 45 | 43 | 9 | 38 | 76 | 1 | 0 | 0 | 0 | 6 | 3 | 2 | 4.13 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 26 | 2006 | R | 93 | 36 | 0 | 4 | 3 | 5.67 | .316 | 1.37 | 9.0 | 3.3 | 9.2 | 54.0 | 54 | 35 | 34 | 6 | 20 | 55 | 0 | 1 | 4 | 0 | 0 | 1 | 0 | 3.57 |
| RP | Timlin, M.Timlin, Mike >> | 36 | 2002 | R | 50 | 39 | 0 | 4 | 4 | 6.46 | .367 | 1.72 | 12.5 | 2.9 | 6.7 | 46.0 | 64 | 33 | 33 | 15 | 15 | 34 | 0 | 4 | 3 | 0 | 0 | 1 | 0 | 6.80 |
| RP | Donnelly, B.Donnelly, Brendan >> | 32 | 2003 | R | 38 | 24 | 0 | 1 | 3 | 4.40 | .348 | 1.53 | 9.9 | 4.2 | 10.5 | 30.2 | 33 | 15 | 15 | 3 | 14 | 35 | 0 | 1 | 1 | 0 | 0 | 2 | 1 | 3.57 |
| SP | Harang, A.Harang, Aaron >> | 29 | 2007 | R | 52 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Kazmir, S.Kazmir, Scott >> | 24 | 2008 | L | 41 | 5 | 0 | 0 | 1 | 8.00 | .400 | 2.00 | 10.0 | 8.0 | 13.0 | 9.0 | 10 | 8 | 8 | 2 | 8 | 13 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 5.67 |