| SP | Schmidt, J.Schmidt, Jason † >> | 30 | 2003 | R | 99 | 30 | 30 | 15 | 8 | 3.02 | .249 | 0.97 | 6.2 | 2.5 | 8.6 | 244.2 | 168 | 85 | 82 | 26 | 69 | 234 | 13 | 0 | 0 | 2 | 22 | 6 | 1 | 3.39 |
| SP | Peavy, J.Peavy, Jake † >> | 26 | 2007 | R | 91 | 29 | 29 | 16 | 7 | 3.64 | .294 | 1.22 | 8.1 | 2.9 | 8.1 | 193.0 | 173 | 79 | 78 | 23 | 62 | 173 | 2 | 0 | 0 | 1 | 18 | 6 | 1 | 3.81 |
| SP | Perez, O.Perez, Odalis † >> | 25 | 2002 | L | 82 | 28 | 28 | 17 | 7 | 3.38 | .260 | 1.03 | 7.2 | 2.1 | 6.2 | 178.1 | 142 | 67 | 67 | 21 | 41 | 122 | 1 | 0 | 0 | 0 | 20 | 5 | 4 | 3.94 |
| SP | Williams, W.Williams, Woody # >> | 36 | 2002 | R | 79 | 27 | 27 | 11 | 6 | 3.76 | .291 | 1.15 | 8.3 | 2.1 | 7.0 | 170.0 | 157 | 73 | 71 | 23 | 39 | 133 | 0 | 0 | 0 | 0 | 17 | 13 | 1 | 4.11 |
| RP | Papelbon, J.Papelbon, Jonathan † >> | 26 | 2006 | R | 93 | 71 | 0 | 9 | 4 | 2.74 | .278 | 1.12 | 7.2 | 2.9 | 9.5 | 95.1 | 76 | 34 | 29 | 10 | 31 | 100 | 0 | 7 | 5 | 0 | 0 | 3 | 4 | 3.34 |
| RP | Marmol, C.Marmol, Carlos † >> | 26 | 2008 | R | 86 | 58 | 0 | 5 | 3 | 2.65 | .272 | 1.12 | 5.8 | 4.3 | 10.8 | 71.1 | 46 | 23 | 21 | 5 | 34 | 85 | 0 | 14 | 4 | 0 | 0 | 0 | 2 | 2.96 |
| RP | Foulke, K.Foulke, Keith >> | 31 | 2003 | R | 78 | 40 | 0 | 3 | 6 | 4.53 | .311 | 1.33 | 9.6 | 2.5 | 6.7 | 43.2 | 46 | 24 | 22 | 11 | 12 | 32 | 0 | 8 | 2 | 0 | 0 | 1 | 0 | 5.74 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 22 | 2004 | R | 68 | 21 | 0 | 1 | 0 | 3.00 | .337 | 1.48 | 8.1 | 5.1 | 10.3 | 21.0 | 19 | 7 | 7 | 2 | 12 | 24 | 0 | 3 | 0 | 0 | 0 | 1 | 0 | 3.81 |
| RP | Rodriguez, F.Rodriguez, Felix >> | 29 | 2001 | R | 58 | 18 | 0 | 0 | 0 | 3.38 | .341 | 1.50 | 7.0 | 7.0 | 9.0 | 18.2 | 14 | 7 | 7 | 5 | 14 | 18 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 7.11 |