| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 25 | 25 | 14 | 4 | 2.44 | .243 | 0.93 | 6.7 | 1.8 | 10.1 | 173.1 | 128 | 48 | 47 | 22 | 34 | 194 | 0 | 0 | 0 | 0 | 20 | 5 | 0 | 3.09 |
| SP | Kershaw, C.Kershaw, Clayton † >> | 28 | 2016 | L | 98 | 24 | 24 | 13 | 7 | 3.13 | .285 | 1.17 | 8.3 | 2.3 | 9.6 | 181.0 | 166 | 70 | 63 | 22 | 46 | 194 | 4 | 0 | 0 | 0 | 19 | 4 | 4 | 3.27 |
| SP | Santana, J.Santana, Johan # >> | 25 | 2004 | L | 91 | 24 | 24 | 8 | 10 | 4.23 | .287 | 1.16 | 8.1 | 2.4 | 8.9 | 161.2 | 145 | 78 | 76 | 16 | 43 | 160 | 3 | 0 | 0 | 1 | 15 | 7 | 4 | 3.24 |
| SP | Hudson, D.Hudson, Daniel # >> | 23 | 2010 | R | 72 | 24 | 24 | 10 | 8 | 6.05 | .347 | 1.57 | 9.9 | 4.3 | 5.9 | 144.1 | 159 | 100 | 97 | 19 | 68 | 95 | 0 | 0 | 0 | 0 | 9 | 3 | 12 | 4.88 |
| SP | Strasburg, S.Strasburg, Stephen >> | 28 | 2017 | R | 67 | 24 | 24 | 13 | 4 | 5.09 | .319 | 1.37 | 8.9 | 3.5 | 9.4 | 148.2 | 146 | 86 | 84 | 29 | 57 | 155 | 0 | 0 | 0 | 0 | 12 | 6 | 2 | 4.73 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 98 | 80 | 0 | 1 | 0 | 3.35 | .301 | 1.25 | 8.2 | 3.2 | 8.0 | 45.2 | 41 | 19 | 17 | 6 | 16 | 40 | 0 | 6 | 0 | 0 | 0 | 2 | 0 | 4.16 |
| RP | Green, C.Green, Chad † >> | 26 | 2017 | R | 95 | 81 | 0 | 2 | 2 | 2.21 | .313 | 1.36 | 7.5 | 4.8 | 10.2 | 73.1 | 61 | 24 | 18 | 4 | 39 | 83 | 0 | 7 | 2 | 0 | 0 | 0 | 3 | 3.04 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 90 | 56 | 0 | 2 | 1 | 4.22 | .292 | 1.16 | 7.5 | 3.1 | 9.7 | 53.1 | 44 | 25 | 25 | 7 | 18 | 57 | 0 | 6 | 0 | 0 | 0 | 4 | 0 | 3.81 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 78 | 42 | 0 | 5 | 7 | 4.20 | .303 | 1.30 | 9.0 | 2.9 | 8.3 | 40.2 | 40 | 19 | 19 | 7 | 13 | 37 | 0 | 5 | 2 | 0 | 0 | 0 | 3 | 4.40 |