| SP | Scherzer, M.Scherzer, Max # >> | 33 | 2017 | R | 97 | 13 | 13 | 7 | 1 | 3.93 | .285 | 1.19 | 7.8 | 2.9 | 9.8 | 89.1 | 77 | 40 | 39 | 13 | 29 | 97 | 0 | 0 | 0 | 0 | 6 | 1 | 0 | 3.73 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 91 | 13 | 13 | 4 | 5 | 3.75 | .306 | 1.29 | 8.6 | 3.1 | 9.4 | 81.2 | 77 | 34 | 34 | 10 | 28 | 85 | 0 | 0 | 0 | 0 | 7 | 3 | 3 | 3.65 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 89 | 13 | 13 | 4 | 6 | 5.83 | .346 | 1.56 | 11.0 | 3.1 | 8.6 | 83.1 | 101 | 55 | 54 | 18 | 29 | 79 | 2 | 0 | 0 | 0 | 5 | 2 | 5 | 5.04 |
| SP | Perez, P.Perez, Pascual >> | 31 | 1988 | R | 78 | 13 | 13 | 5 | 6 | 4.58 | .333 | 1.46 | 8.5 | 4.7 | 5.2 | 90.1 | 85 | 51 | 46 | 18 | 47 | 52 | 1 | 0 | 0 | 0 | 7 | 3 | 1 | 6.11 |
| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 71 | 13 | 12 | 6 | 4 | 4.15 | .322 | 1.41 | 8.5 | 4.2 | 6.6 | 78.0 | 74 | 37 | 36 | 11 | 36 | 57 | 1 | 0 | 0 | 0 | 5 | 1 | 4 | 4.79 |
| RP | Benoit, J.Benoit, Joaquin >> | 33 | 2010 | R | 93 | 37 | 0 | 3 | 2 | 2.54 | .295 | 1.21 | 7.2 | 3.7 | 10.6 | 39.0 | 31 | 13 | 11 | 4 | 16 | 46 | 0 | 2 | 0 | 0 | 0 | 2 | 2 | 3.36 |
| RP | Gossage, R.Gossage, Rich >> | 30 | 1981 | R | 88 | 35 | 0 | 0 | 4 | 3.82 | .303 | 1.27 | 6.4 | 5.1 | 9.3 | 35.1 | 25 | 16 | 15 | 5 | 20 | 36 | 0 | 4 | 2 | 0 | 0 | 1 | 2 | 4.60 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 78 | 18 | 0 | 0 | 2 | 5.09 | .346 | 1.58 | 10.6 | 4.2 | 9.0 | 17.2 | 20 | 11 | 10 | 2 | 8 | 17 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 3.94 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 75 | 13 | 0 | 1 | 1 | 3.00 | .345 | 1.58 | 9.8 | 4.5 | 9.8 | 12.0 | 13 | 4 | 4 | 1 | 6 | 13 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.42 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 74 | 6 | 0 | 0 | 0 | 9.00 | .400 | 2.00 | 9.0 | 9.0 | 6.8 | 8.0 | 8 | 8 | 8 | 2 | 8 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 7.75 |
| SP | Lincecum, T.Lincecum, Tim >> | 25 | 2009 | R | 57 | 1 | 0 | 0 | 1 | - | 1.000 | - | - | - | - | 0.0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | - |