| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 90 | 13 | 13 | 5 | 6 | 3.30 | .268 | 1.09 | 7.5 | 2.3 | 7.3 | 101.0 | 84 | 38 | 37 | 13 | 26 | 82 | 2 | 0 | 0 | 0 | 9 | 1 | 0 | 3.85 |
| SP | Snell, B.Snell, Blake # >> | 25 | 2018 | L | 88 | 13 | 13 | 7 | 5 | 4.22 | .270 | 1.09 | 7.3 | 2.4 | 9.2 | 81.0 | 66 | 43 | 38 | 13 | 22 | 83 | 1 | 0 | 0 | 1 | 7 | 2 | 7 | 3.93 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 68 | 13 | 13 | 4 | 7 | 4.59 | .313 | 1.34 | 7.1 | 5.1 | 7.1 | 80.1 | 63 | 42 | 41 | 10 | 45 | 63 | 0 | 0 | 0 | 0 | 5 | 2 | 2 | 4.81 |
| RP | Chapman, A.Chapman, Aroldis >> | 24 | 2012 | L | 87 | 31 | 0 | 3 | 0 | 1.44 | .238 | 0.87 | 5.0 | 2.9 | 10.0 | 43.2 | 24 | 7 | 7 | 2 | 14 | 48 | 0 | 1 | 4 | 0 | 0 | 3 | 1 | 2.56 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 84 | 24 | 0 | 3 | 2 | 2.86 | .248 | 0.99 | 7.4 | 1.6 | 7.1 | 28.1 | 23 | 9 | 9 | 4 | 5 | 22 | 0 | 4 | 1 | 0 | 0 | 0 | 0 | 3.82 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 79 | 16 | 0 | 1 | 1 | 2.20 | .269 | 1.10 | 7.3 | 2.8 | 7.3 | 16.1 | 13 | 4 | 4 | 2 | 5 | 13 | 0 | 6 | 1 | 0 | 0 | 0 | 0 | 3.94 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 64 | 5 | 0 | 0 | 0 | 0.00 | .143 | 0.50 | 1.5 | 3.0 | 10.5 | 6.0 | 1 | 0 | 0 | 0 | 2 | 7 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1.67 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 62 | 10 | 0 | 1 | 0 | 0.00 | .174 | 0.63 | 5.3 | 0.8 | 8.3 | 12.2 | 7 | 0 | 0 | 0 | 1 | 11 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.42 |
| SP | Darvish, Y.Darvish, Yu >> | 26 | 2013 | R | 55 | 3 | 0 | 0 | 0 | 1.50 | .200 | 0.58 | 3.8 | 1.5 | 11.3 | 12.0 | 5 | 2 | 2 | 1 | 2 | 15 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 2.58 |