| SP | McNally, D.McNally, Dave >> | 26 | 1968 | L | 96 | 18 | 18 | 8 | 9 | 4.41 | .302 | 1.27 | 8.3 | 3.2 | 4.9 | 136.2 | 125 | 67 | 67 | 14 | 48 | 74 | 5 | 0 | 0 | 1 | 9 | 4 | 1 | 4.40 |
| SP | Mathewson, C.Mathewson, Christy † # >> | 28 | 1908 | R | 82 | 17 | 17 | 10 | 5 | 2.60 | .236 | 0.92 | 7.0 | 1.2 | 5.4 | 138.1 | 108 | 41 | 40 | 10 | 19 | 83 | 10 | 0 | 0 | 4 | 11 | 1 | 0 | 3.17 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 17 | 17 | 4 | 11 | 6.44 | .355 | 1.63 | 10.6 | 4.1 | 5.0 | 109.0 | 128 | 79 | 78 | 15 | 50 | 60 | 1 | 0 | 0 | 0 | 4 | 2 | 2 | 5.12 |
| SP | Gooden, D.Gooden, Dwight >> | 21 | 1985 | R | 68 | 16 | 16 | 7 | 7 | 4.87 | .319 | 1.40 | 9.5 | 3.2 | 6.2 | 114.2 | 120 | 65 | 62 | 19 | 40 | 78 | 1 | 0 | 0 | 0 | 8 | 1 | 6 | 4.88 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 42 | 0 | 0 | 3 | 2.89 | .263 | 1.07 | 5.9 | 3.7 | 7.9 | 56.0 | 37 | 18 | 18 | 4 | 23 | 49 | 0 | 6 | 2 | 0 | 0 | 0 | 1 | 3.41 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 82 | 34 | 0 | 3 | 1 | 4.10 | .287 | 1.21 | 7.1 | 3.9 | 8.3 | 37.1 | 29 | 17 | 17 | 3 | 16 | 34 | 0 | 3 | 2 | 0 | 0 | 0 | 3 | 3.51 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 67 | 19 | 0 | 1 | 1 | 2.53 | .326 | 1.45 | 6.4 | 6.9 | 6.0 | 21.1 | 15 | 6 | 6 | 1 | 16 | 14 | 0 | 2 | 1 | 0 | 0 | 0 | 1 | 4.57 |
| RP | Urbina, U.Urbina, Ugueth >> | 24 | 1998 | R | 58 | 13 | 0 | 0 | 1 | 0.63 | .218 | 0.84 | 3.9 | 3.9 | 10.3 | 14.1 | 6 | 1 | 1 | 1 | 6 | 16 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 2.93 |
| RP | O'Day, D.O'Day, Darren >> | 28 | 2010 | R | 50 | 15 | 0 | 0 | 0 | 7.63 | .378 | 1.76 | 14.4 | 1.8 | 5.4 | 15.1 | 24 | 13 | 13 | 4 | 3 | 9 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 6.07 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 58 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | McGinnity, J.McGinnity, Joe >> | 33 | 1904 | R | 50 | 5 | 0 | 0 | 1 | 14.40 | .483 | 2.80 | 21.6 | 3.6 | 7.2 | 5.0 | 12 | 9 | 8 | 2 | 2 | 4 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 7.80 |